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Amphotericin B Basic information

Pharmacology and mechanism of action Indications Side effects Contraindications and precautions Preparations Interactions Polyene antifungal antibiotics Pharmacokinetic Indications Side effects Drug interactions Amphotericin B liposome Amphotericin B and Nephrotoxicity Chemical properties Uses Production methods Category References Acute toxicity Flammability and hazard characteristics Storage and transport properties Fire extinguishing agent

Product Name: Amphotericin B

Synonyms: FUNGIZONE;FUNGIZONE(R);ABELCET;AMBISOME;AMPHOTERCIN B;AMPHOTERICIN B;AMPHOTERICIN B SOLUBILIZED;AMPHOTERICIN B, SOLUBLE

CAS: 1397-89-3

MF: C47H73NO17

MW: 924.08

EINECS: 215-742-2

Product Categories: Miscellaneous Natural Products;Antibiotic Explorer;AM to AQAntibiotics;MLS;A;Alphabetic;Chemical Structure;Inhibitors;Antibiotics A to;Antibiotics A-FAntibiotics;AntibioticsAntibiotics;AntifungalAntibiotics;Cell Culture;Intermediates & Fine Chemicals;Pharmaceuticals;ABELCET;antibiotic;Carbohydrates & Derivatives;Chiral Reagents;Antifungal;Chemical Structure Class;Interferes with Cell Membrane Permeability (Ionophores)Antibiotics;Mechanism of Action;Polyenes;Reagents and Supplements;Spectrum of Activity;APIs

Mol File: 1397-89-3.mol

Amphotericin B Structure

Amphotericin B Chemical Properties

Melting point >170°C

alpha D24 +333° (acidic DMF); -33.6° (0.1N methanolic HCl)

Boiling point 804.34°C (rough estimate)

density 1.34

refractive index 1.5280 (estimate)

storage temp. 2-8°C

solubility sterile water: 20 mg/mL as a stock solution. Stock solutions should be stored at −20 #x00b0;C. Stable at 37 #x00b0;C for 3 days.

pka pKa ～5.7(DMF/H2O) (Uncertain)

form powder

color yellow

Water Solubility <0.1 g/100 mL at 21 ºC

Sensitive Moisture & Light Sensitive

Merck 13,590

BRN 78342

Stability: Stable, but may be light sensitive. Incompatible with strong oxidizing agents.

InChIKey APKFDSVGJQXUKY-INPOYWNPSA-N

CAS DataBase Reference 1397-89-3(CAS DataBase Reference)

EPA Substance Registry System Amphotericin B (1397-89-3)