[The most commonly used antibiotics]
Azithromycin because of side effects is less than cephalosporins antibiotics, is our country hospital for clinical bacterial infection related diseases treatment of one of the most commonly used antibiotic medicines, the medicine belongs to the large ring lactone class of the second generation of semisynthetic derivatives, differs from that of erythromycin in the structure, it in erythromycin 9 a locus of lactone ring insert a methyl replace nitrogen, to produce a large ring lactone 15 yuan.
The mechanism of action of azithromycin is similar to that of erythromycin. By binding to the 50S subunit of the sensitive bacterial ribosome, azithromycin inhibits the synthesis of RNA-dependent proteins and thus plays an antibacterial role, preserving the antibacterial spectrum of typical erythromycin. The activity against chlamydia was similar to that of erythromycin.
Compared with erythromycin, the antibacterial activity against gram-negative bacteria was significantly improved. The antibacterial activity against influenzobacter influenzobacter and Neisseria gonorrhoeae was more than 4 times stronger than that against Erythromycin, and the antibacterial activity against Legionella was about 2 times stronger than that against Legionella. The antibacterial activity against Enterobacteriaceae was also significantly stronger than that against Erythromycin.
The MIC for most Gram-negative bacteria was less than 1μg/ mL. Staphylococcus aureus and streptococcus pyogenes were cross-resistant to this product and erythromycin. It also has a good killing effect on toxoplasmosis and treponema pallidum. Azithromycin is mainly used for respiratory tract infection, urogenital tract infection, skin and soft tissue infection and sexually transmitted diseases caused by sensitive microorganisms.