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250 Milligram |
FOB Price: USD 2370.0000 |
Follastatin 344 Follastatin 344 1010396-29-8
purity min99%
Large volume discount
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Product name |
Follastatin 344 |
CAS No. |
1010396-29-8 |
Other Names |
Follastatin 344 |
Molecular Formula |
C6H8O6 |
Molecular weight |
/ |
Grade Standard |
Medicine Grade |
COA |
Avaliable |
Follistatin (FST) is a secreted glycoprotein that was first identified as a follicle-stimulating hormone inhibiting substance in ovarian follicular fluid (1, 2). Human Follistatin cDNA encodes a 344 amino acid (aa) protein with a 29 aa signal sequence, an N-terminal atypical TGF binding domain, three Follistatin domains that contain EGF-like and kazal-like motifs, and a highly acidic C-terminal tail. Follistatin is a secreted protein that binds to ligands of the TGF-Beta family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-Beta ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-Beta1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 37.8 kDa protein containing 344 amino acids.
C50H69N15O9
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