CasNo.56390-09-1,Epirubicin Hydrochloride,(56390-09-1) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Epirubicin hydrochloride Manufacturer/High quality Epirubicin HCL High purity 99% Epirubicin hcl Supplier in china

Quick Details

Appearance:Orange-red crystalline powder
Application:Used as an antineoplastic
PackAge:Cardboard barrel
ProductionCapacity:1|Gram|Day
Storage:Store under shade and cool environment without direct sunlight after sealing.
Transportation:During the transportation process, all containers should be free of leak, falling, collapse and damage. All products transported in tanker should be kept no less than 25℃ to facilitate.

Superiority:

		Hangzhou Benoy Chemical Co., Ltd is a scientific and technological enterprise dedicated to the R &amp; D, production and operation of chemical raw materials, pharmaceutical intermediates and APIs. At present, the company has one R &amp; D center and two production bases. The company has more than 10 full-time personnel engaged in the research and development of APIs and pharmaceutical intermediates, including 2 with doctor's degree, 5 with master's degree, 2 with Professor of Zhejiang University of technology as the chief consultant of the company, with strong scientific research force and rich practical experience. The laboratory is equipped with advanced ultra-high performance liquid chromatography, gas chromatography and relatively complete conventional experimental equipment. Many products have been successfully developed and put into industrial production. The company adheres to the quality and environment policy of "customer first, continuous innovation", and excellent products win good market reputation for the company. At present, the products are exported to Europe, the United States, Southeast Asia and other countries and regions. It is the company's business philosophy to guide technology with information, guarantee quality with technology and win market with quality. The company will give full play to its own advantages and devote itself to the specialization and serialization of pharmaceutical intermediates, so as to provide customers with high-quality, environmental protection and safety products. The company will also be honest, trustworthy, mutually beneficial and co-existence purposes, is willing to sincerely cooperate with customers at home and abroad, hand in hand.

		Fast shipment by well-reputed shipping line;

		Packaging with pallets according to buyers’ special request;

		Cargoes together with container sales service available;

		Providing best service after shipment by e-mail;

		Providing photos of cargoes before and after loading into container;

		If you want to find the best price of product, please contact Benoy Chemical.Emial:sales@benoychem.com

Details:

Epirubicin hydrochloride Basic information

Product Name:	Epirubicin hydrochloride
Synonyms:	CS-1396;Epirubicin hydrochloride, ≥90% (HPLC);Epirubicin Hydrochloride - CAS 56390-09-1 - Calbiochem;epi-Doxorubicin HCl;Epirubicin HCl (4'-epidoxorubicin);ELLENCE; PHARMORUBICIN; EPIRUBICIN EBEWE;Epirubicin Ebewe;Epirubicin hydrochloride, >=99%
CAS:	56390-09-1
MF:	C27H30ClNO11
MW:	579.9802

Epirubicin hydrochloride Chemical Properties

Melting point	185°C dec.
alpha	D20 +274° (c = 0.01 in methanol)
RTECS	QI9295750
Fp	443.8℃
storage temp.	Desiccate at +4°C
solubility	Soluble in DMSO to 100mM, or in ethanol to 10mM
form	powder
color	red to deep red

Epirubicin hydrochloride Usage And Synthesis

Description	Epirubicin hydrochloride is an antitumor antibiotic which is epimeric with doxorubicin a t the 4’-position of the amino sugar moiety. It has shown utility in the treatment of mammary, gastric, colorectal, pulmonary and ovarian carcinomas, as well as malignant lymphoma and melanoma and soft tissue sarcoma. It is reported to be less sardiotoxic than doxorubicin.
Chemical Properties	Orange-Red Crystalline Solid
Originator	Erbamont (Italy)
Uses	Used as an antineoplastic
Brand name	Ellence(Pfizer);FARMORUBICIN.
Biological Functions	This stereoisomer of doxorubicin has the 4′-hydroxy group of the daunosamine sugar oriented in the β-position . Epirubicin will be slowly reduced to the active C13 alcohol (epirubicinol), giving it a 30- to 38-hour half life, which is similar to that of doxorubicin. Unlike doxorubicinol, however, which was equally active with doxorubicin, epirubicinol has only one-tenth the activity of its parent drug and is not believed to contribute significantly to the therapeutic action of this agent.
Biological Activity	Antibiotic antitumor agent. Inhibits the synthesis and function of DNA (IC 50 = 62.7 μ M in rat glioblastoma cell lines) and inhibits the relaxing property of topoisomerase II.
Clinical Use	Epirubicin is indicated for use in breast cancer, and the starting dose is 100 to 120 mg/m2 (compared to a starting dose of 60–75 mg/m2 for doxorubicin).
Side effects	The side effects and precautions are as outlined previously for doxorubicin, although there is a lower risk of serious myocardial toxicity or myelotoxicity.
Metabolism	Cleavage of the epimerized sugar will occur before excretion, generating an aglycone that is indistinguishable from that generated by doxorubicin. Although excretion is primarily biliary, dosage reduction in severe renal impairment, as well as in hepatic dysfunction, is warranted.