Valecoxib

Min.Order / FOB Price:Get Latest Price

1 Gram	Negotiable

1 Gram

Negotiable

Min.Order :1 Gram
Purity: 99%
Payment Terms : L/C,D/A,D/P,T/T,Other

Keywords

Valdecoxib Manufacturer/High quality/Best price/In stock Intermediate of parecoxib sodium Valecoxib Supplier in china

Quick Details

Appearance:White crystalline powder
Application:Intermediate of parecoxib sodium
PackAge: According to customer requirements
ProductionCapacity:1|Kilogram|Day
Storage:Store under shade and cool environment without direct sunlight after sealing.
Transportation:During the transportation process, all containers should be free of leak, falling, collapse and damage. All products transported in tanker should be kept no less than 25℃ to facilitate.

Superiority:

	Hangzhou Benoy Chemical Co., Ltd is a scientific and technological enterprise dedicated to the R &amp; D, production and operation of chemical raw materials, pharmaceutical intermediates and APIs. At present, the company has one R &amp; D center and two production bases. The company has more than 10 full-time personnel engaged in the research and development of APIs and pharmaceutical intermediates, including 2 with doctor's degree, 5 with master's degree, 2 with Professor of Zhejiang University of technology as the chief consultant of the company, with strong scientific research force and rich practical experience. The laboratory is equipped with advanced ultra-high performance liquid chromatography, gas chromatography and relatively complete conventional experimental equipment. Many products have been successfully developed and put into industrial production. The company adheres to the quality and environment policy of "customer first, continuous innovation", and excellent products win good market reputation for the company. At present, the products are exported to Europe, the United States, Southeast Asia and other countries and regions. It is the company's business philosophy to guide technology with information, guarantee quality with technology and win market with quality. The company will give full play to its own advantages and devote itself to the specialization and serialization of pharmaceutical intermediates, so as to provide customers with high-quality, environmental protection and safety products. The company will also be honest, trustworthy, mutually beneficial and co-existence purposes, is willing to sincerely cooperate with customers at home and abroad, hand in hand.

	Fast shipment by well-reputed shipping line;

	Packaging with pallets according to buyers’ special request;

	Cargoes together with container sales service available;

	Providing best service after shipment by e-mail;

	Providing photos of cargoes before and after loading into container;

	If you want to find the best price of product, please contact Benoy Chemical.Emial:sales@benoychem.com

Details:

Valdecoxib is a second-generation COX-2 inhibitor, developed as a follow-up to celecoxib for the oral once-daily treatment of osteoarthritis, adult rheumatoid arthritis and menstrual pain. The first step for the preparation of valdecoxib is the conversion of deoxybenzoin to its corresponding oxime. Deprotonation of this oxime with butyl lithium followed by condensation with ethyl acetate gave the corresponding isoxazoline, which, after treatment with chlorosulfonic acid and reaction with aqueous ammonia afforded valdecoxib. Valdecoxib is approximately 28,000-fold more selective against human recombinant COX-2 than human recombinant COX-1. In an ex viva human whole blood assay, the I&O values against COX-2 and COX-1 were respectively 0.89 PM and 25.4 FM. In animal models, valdecoxib possesses excellent oral activity as an antiinflammatory. In rats, valdecoxib potently inhibited carrageenan footpad edema and adjuvant-induced arthritis. In the rat carrageenan air pouch model of inflammation, valdecoxib showed an efficient inhibition of prostaglandin production. In pharmacokinetic studies, valdecoxib has a rapid onset of action (tmax= 2.25h) and a prolonged duration of action (t1/2= 8 h).

Valdecoxib is a substrate of CYP3A4 but no metabolism interference was seen with commonly used synthetic narcotics, alfentanil and fentanyl. Clinical studies have shown that valdecoxib is as effective as naproxen in treating osteoarthritis, rheumatoid arthritis and dysmenornhoea. The efficacy of valdecoxib was also demonstrated in managing postoperative pain (oral and orthopedic surgery) with effective analgesia and time to rescue medication superior to those obtained with rofecoxib. Several clinical trials showed that valdecoxib has a better upper gastrointestinal safety profile compared to naproxen, ibuprofen or diclofenac and does not affect platelet function. Less abdominal pain, dyspepsia and constipation were observed with valdecoxib than with naproxen. Valdecoxib is contraindicated in patients with a history of allergic react

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