Sell high-quality PTEROIC ACID with best price 119-24-4 Pteroic acid Manufacturer in china/High Purity Best Price Manufacturer in china/High Purity Best Price Pteroic acid
PTEROIC ACID Basic information |
Product Name: | PTEROIC ACID |
Synonyms: | 4-[(2-amino-4-keto-1H-pteridin-6-yl)methylamino]benzoic acid;4-[(2-amino-4-oxo-1H-pteridin-6-yl)methylamino]benzoic acid;4-[(2-azanyl-4-oxo-1H-pteridin-6-yl)methylamino]benzoic acid;4-{[(2-Amino-4-hydroxypteridin-6-yl)methyl]amino}benzoic acid;4-[[(2-AMino-3,4-dihydro-4-oxo-6-pteridinyl)Methyl]aMino]benzoic Acid;NSC 14972;p-[(2-AMino-4-hydroxy-6-pteridylMethyl)aMino]benzoic Acid;Pyrofolic acid |
CAS: | 119-24-4 |
MF: | C14H12N6O3 |
MW: | 312.28 |
PTEROIC ACID Chemical Properties |
Melting point | >400℃ |
Boiling point | 610.0±65.0 °C(Predicted) |
density | 1.69 |
storage temp. | 2-8°C |
PTEROIC ACID Usage And Synthesis |
Uses | Pteroic Acid is a constituent as well as a degradation product of Folid Acid (F680300) formed via anzymatic hydrolysis. has been shown to activate the glutamylation of methotrexate by folylpolyglutama te synthetase. |
Enzyme inhibitor | This metabolite (FWfree-acid = 312.29 g/mol; CAS 119-24-4), also known as 4-[[(2-amino-1,4-dihydro-4-oxo-6-pteridinyl)methyl]amino]benzoic acid, is a structural component of folates. Pteroic acid is a growth factor for a number of Enterococci. Pteroic acid is a yellow powder that is slightly soluble in aqueous NaOH. The lmax values in 0.1 M NaOH are 255, 275, and 365 nm (e = 26300, 23400, and 8900 M–1cm–1, respectively). Target(s): arylamine N-acetyltransferase; dihydrofolate reductase; dihydrofolate synthetase, weakly inhibited; dihydropteroate synthase; glutamate carboxypeptidase; and xanthine oxidase. |
Purification Methods | Crystallise it from dilute HCl. Dry it in vacuo. Hygroscopic IRRITANT. [Nair et al. J Org Chem 46 3152 1981, Beilstein 26 III/IV 3942.] |
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