Reliable quality 53910-25-1 PENTOSTATIN CL-67310465 co-vidarabine
PENTOSTATIN Basic information |
Product Name: | PENTOSTATIN |
Synonyms: | CL-67310465:NSC-218321;(8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol;Pentostatin(Deoxycoformycin);Pentostatin, >=99%;ci-825;cl67310465;co-vidarabine;dcf |
CAS: | 53910-25-1 |
MF: | C11H16N4O4 |
MW: | 268.27 |
PENTOSTATIN Chemical Properties |
Melting point | 154-157 C |
alpha | D25 +76.4° (c = 1 in water); D23 +73.0° (c = 1, pH 7 buffer) |
Boiling point | 411.43°C (rough estimate) |
density | 1.2576 (rough estimate) |
refractive index | 1.6081 (estimate) |
storage temp. | Store at +4°C |
solubility | H2O: soluble10mg/mL, clear |
form | White solid |
pka | 5.2(at 25℃) |
color | white to beige |
optical activity | [α]/D +70 to +80°, c = 1 in H2O |
PENTOSTATIN Usage And Synthesis |
Description | Pentostatin, an adenosine deaminase inhibitor, is an orphan drug introduced for the treatment of hairy cell leukemia. The agent is considered a significant advance over alpha-interferon, the only other drug available for this indication. The majority of patients treated with pentostatin have been reported to remain in remission for at least four years. It is also under investigation for the treatment of other kinds of leukemia and in transplant rejection. |
Chemical Properties | White Solid |
Originator | Warner-Lambert (Parke-Davis) (U.S.A.) |
Uses | Pentostatin is a potent antitumour antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumour agent. |
Uses | Pentostatin is a potent antitumor antibiotic isolated from a Streptomyces species. Pentostatin is a potent inhibitor of adenine deaminase and has been used therapeutically as an antitumor agent. |
Uses | An adenosine deaminase inhibitor used as an anti-cancer therapeutic drug. Shown to be effective in the treatment of hairy cell leukemia as well as having use in the treatment of other types of cancer such as chronic lymphocytic leukemia. |
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