Pirarubicin hydrochloride THP-ADM THEPRUBICIN
Pirarubicin Basic information |
Product Name: | Pirarubicin |
Synonyms: | THP-ADM;THEPRUBICIN;(8s-cis)-droxyacetyl)-1-methoxy;(8S,10S)-10-[[3-Amino-2,3,6-trideoxy-4-O-[(2R)-tetrahydro-2H-pyran-2-yl]-a-L-lyxo-hexopyranosyl]oxy]-7,8,9,10-tetrahydro-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,12-naphthacenedione;Tepirubicin;Therarubiein;THP-adriamycin;(8S,10S)-10-[(2S,4S,5S,6S)-4-Amino-6-methyl-5-[(2S)-oxan-2-yl]oxy-oxan-2-yl]oxy-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione |
CAS: | 72496-41-4 |
MF: | C32H37NO12 |
MW: | 627.64 |
Pirarubicin Chemical Properties |
Melting point | 188-192°C (dec.) |
alpha | D25 +175 ±25° (c = 0.2 in CHCl3) |
Boiling point | 834.7±65.0 °C(Predicted) |
density | 1.51±0.1 g/cm3(Predicted) |
storage temp. | 2-8°C |
solubility | ethanol: soluble25mg/mL |
pka | 7.35±0.60(Predicted) |
form | powder |
Pirarubicin Usage And Synthesis |
Description | Pirarubicin is a new anthracycline anticancer agent structurally related to doxorubicin. In acute leukemia, non-Hodgkin’s lymphoma, breast and ovariail carcinoma, pirarubicin is reportedly superior to doxorubicin and better tolerated. Its major side-effect appears to be myelosuppression, mainly in the form of leucopenia, which is potentially dose-limiting. |
Chemical Properties | Red Solid |
Originator | Meiji Seika (Japan) |
Uses | Structural analog of Doxorubicin. Antineoplastic |
Brand name | Pinorubicin; Therarubucin |
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