CasNo.1029877-94-8,Trelagliptin succinate,High Purity,(1029877-94-8) Suppliers

1 Gram	Negotiable

Min.Order :1 Gram
Purity: ≥99.0%
Payment Terms : T/T,Other

Keywords

Trelagliptin succinate 1029877-94-8 SYR-472

Quick Details

Appearance:White to off-white crystalline powder
Application:Pharmaceutical intermediates
PackAge:1kg/bag, 10kg/drum, 25kg/drum (on request)
ProductionCapacity:1|Metric Ton|Month
Storage:Cool, shading, dry and sealed
Transportation:air,sea,courier

Superiority:

TRELAGLIPTIN SUCCINATE (1029877-94-8)

Information

Canagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor. It is mainly used clinically for adult type 2 diabetes, as an adjuvant treatment for diet control and exercise therapy.

Quality

Advanced technology

Supper quality

Effective & safety package

Service

Professional and timely afte-sale service(replied within 12h)

COMPANY INFORMATION

Jinan Kangcheng Pharmaceutical Technology Co., Ltd.

Add:Jinan Area,China(Shandong) Pilot Free Trade Zone,China

The company focuses on the development and transfer of pharmaceutical technology. It is a modern enterprise integrating technology development, transfer and sales of APIs, pharmaceutical intermediates, and nutraceutical raw materials.

The company adheres to the principle of integrity and innovation, and provides customers with professional products and advanced technical services.

Details:

TRELAGLIPTIN SUCCINATE
Product infomation	English Name：Trelagliptin succinate
	English Alias：SYR-472
	Chinese Name：琥珀酸曲格列汀
	Chinese Names：曲格列汀琥珀酸盐;琥珀酸盐曲格列汀；CS-924;曲格列汀2;曲格列汀琥珀酸;2-[[6-[(3R)-3-氨基-1-哌啶基]-3,4-二氢-3-甲基-2,4-二氧代-1(2H)-嘧啶基]甲基]-4-氟-苯甲腈琥珀酸盐
	CAS号：1029877-94-8
	Formula：C22H26FN5O6
	Molecular weight：475.47

	Appearance：White to off-white crystalline power
	Purity：99.0%
Use&Pharmacology	Troxagliptin succinate is used for the treatment of type 2 diabetes. Using DPP-4 taken from Caco-2 cells as the material, the IC50 of troxagliptin was determined to be 5.4nmol/L; and using human, dog, and mouse plasma DPP-4 as the material, the IC50 of troxagliptin was determined IC50 is 4.2nmol/L, 6.2nmol/L and 9.7nmol/L, respectively. The inhibitory ability of troxagliptin on human DPP-4 recombinant protein is better than that of alogliptin and sitagliptin, with IC50 values of 1.3nmol/L, 5.3nmol/L and 16.0nmol/L, respectively. In the enzyme specificity experiment, troxagliptin has extremely low inhibitory ability on DPP-2, DPP-8, DPP-9, prolyl endopeptidase and fibroblast activation protein alpha, and the specificity is greater than 10,000 times. . Further research also found that troxagliptin competitively inhibits DPP-4 and has the characteristics of a slow binding mode.
Package&Storage	Package：1kg/bag, 10kg/drum, 25kg/drum (on request)
Package&Storage	Storage&Validity：Cool, shading, dry and sealed/2years
Remarks	If the compound involves patent protection, please do not use it for commercial purposes, but only for scientific research.