Tenofovir disoproxil fumarate 202138-50-9 pharmaceutical intermediates
Tenofovir fumarate is a nucleotide antiviral drug developed and marketed by Gilead company in the United States. It was approved by FDA in 2001 for the treatment of human immunodeficiency virus infection. It was listed in the European Union in 2002 and approved for the treatment of HIV-1 and chronic hepatitis B.
Tenofovir fumarate, as a nucleotide reverse transcriptase inhibitor, is an oral cyclic open nucleotide phosphate prodrug, which is rapidly converted into tenofovir after oral absorption.
Due to its high bioavailability, definite efficacy and good tolerance, TDF has become the recommended first-line anti HIV drug with the highest sales.
Nucleotide reverse transcriptase inhibitor, a prodrug of tenofovir (PMPA, 2), is mainly used in the treatment of human immunodeficiency virus infection
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