Osimertinib Mesylate 1421373-66-1 Osimertinib Mesylate 1421373-66-1
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CAS |
1421373-66-1 |
MF |
|
MW |
595.71298 |
EINECS |
200-064-1 |
Grade Standard |
Medicine Grade, Tech Grade |
Type |
Auxiliaries and Other Medicinal Chemicals |
Appearance |
White Powder |
Storage |
|
Application |
|
Description |
Osimertinib is active against exon 19 deletions, exon 21 mutations, and also the exon 20 T790M mutations. It is preferentially selective for mutated EGFR, and therefore toxicity at therapeutic doses is lower than for first- and second-generation agents. Notably, osimertinib is able to cross the blood-brain barrier, making it active against disease in the CNS. |
Definition |
ChEBI: A methanesulfonate (mesylate) salt prepared from equimolar amounts of osimertinib and methanesulfonic acid. Used for treatment of EGFR T790M mutation positive non-small cell lung cancer. |
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