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L-glutathione 70-18-8 GSH
Product Introduction
What is L-glutathione?
Glutathione (GSH) is named Reduced glutathione or L-GlutathioneReduced ,an important antioxidant in plants, animals, fungi, and some bacteria and archaea,a white crystalline powder. It is atripeptide with a gamma peptide linkage between the carboxyl group of the glutamate side chain and the amine group of cysteine, and the carboxyl group of cysteine is attached by normal peptide linkage to a glycine.Thiol groups are reducing agents, existing at a concentration around 5 mM in animal cells. Glutathione reduces disulfide bonds formed within cytoplasmicproteins to cysteines by serving as an electron donor. In the process, glutathione is converted to its oxidized form, glutathione disulfide (GSSG), also called L-glutathione.
Specification
Name: |
L-glutathione |
Molecular formula: |
C10H17N3O6S |
|
Cas No: |
70-18-8 |
Grade: |
Food Grade ,Medical Grade |
|
ITEM |
SPECIFICATION |
METHOD REFERENCE |
||
Appearance |
White crystalline powder |
Visual |
||
Ammonium |
≤200ppm |
Glutathione USPmonograph |
||
Chloride |
≤200ppm |
USP35<221> |
||
Sulfate |
≤300ppm |
USP35<221> |
||
Iron |
≤10ppm |
USP35<241> |
||
Arsenic |
≤2ppm |
USP35<211> |
||
Heavy metals |
≤10ppm |
USP35<231>Method I |
||
Loss on drying(3h at 105 ℃) |
≤0.5% |
USP35<731> |
||
Residue on Ignition |
≤0.1% |
USP35<281> |
||
L-glutathione oxidized |
≤1.5% |
Glutathione USP monograph |
||
Total impurities |
≤2.0% |
Glutathione USP monograph |
||
Assay(dry basis) |
98.0% to 101.0% |
Glutathione USP monograph |
||
Function
1.It maintains levels of reduced glutaredoxin and glutathione peroxidase.
2.It is one of the major endogenous antioxidants produced by the cells, participating directly in the neutralization of free
radicals and reactive oxygen compounds, as well as maintaining exogenous antioxidants such as vitamins C and E in their reduced (active) forms.
3.It is used in metabolic and biochemical reactions such as DNA synthesis and repair, protein synthesis, prostaglandin synthesis,amino acid transport, and enzyme activation. It has a vital function in iron metabolism. Yeast cells depleted of GSH or containing toxic levels of GSH show an intense iron starvation-like response and impairment of the activity of extramitochondrial ISC enzymes thus inhibiting oxidative endoplasmic reticulum folding, followed by death.
4.Glutathione plays an important role in preventing oxidative damage to the skin.
5.Glutathione has also been associated with skin lightening ability.
6.Glutathione utilizes different mechanisms to exert its action as a skin whitening agent at various levels of melanogenesis.
Application
Drug applications:
1.Protect the liver and treat liver-related diseases.
2.Treat tumors and reduce side effects of chemotherapy and radiotherapy.
3.Glutathione as an antidote, can combine with toxic compounds, heavy metal ions or carcinogenic substances to promote their excretion. It can be used for the detoxification treatment of acrylonitrile, fluoride, carbon monoxide, heavy metals and other organic solvents.
4.Treat ophthalmic diseases, especially cataracts.
5.Glutathione can regulate the imbalance of acetylcholine and cholinesterase. It plays an anti-allergic role.
6.Recent studies indicated that glutathione may also have the effect of inhibiting AIDS virus.
Food and applications:
1.Glutathione equivalent to vitamin C, can be added to yogurt and baby food and play a stabilizing role;
2.Since glutathione can prevent pigmentation, it can be added to canned fruits to prevent Browning;
3.Because of the reducibility of Glutathione, it can be added to the flour products to play a reduction role and strengthen the amino acid;
4.Adding Glutathione to bread can shorten the mixing time in the manufacturing process
5.Glutathione has a strong meat flavor when mixed with L-glutamate, nucleic acid flavoring substances or their mixture.
Glutathione can inhibit nucleic acid and enhance flavor in fish cake.
6.Glutathione can enhance flavor in meat, cheese and other food products.
7.Different types of functional food and health food are prepared with glutathione as the functional active factor.
Cosmetics and applications:
1.Glutathione can purify cytotoxic substances. The use in skin care products can treat and relieve excessive heavy metals in the skin and toxins in dust.
2.Glutathione is an anti-aging antioxidant. It can remove free radicals in the body and maintain biological activity of proteins and enzymes. It is the main free radical scavenger in the body, so that the free radical scavenging reaction can continue.
3.Glutathione has an excellent whitening effect by transdermal absorption. It inhibits the production of free radicals and
peroxides from melanin to reduce the biochemical activities of melanocytes and neutralize the toxic substances from pigment cell.
It eventually protects pigment cells from necrosis and metamorphism.
Q&A:
1.Are you a manufacturer or trade company
We have our own factory which located in Zhejiang,China.Meanwhile,we also have many parter factorier,so we can supply many kinds of relative products with very competitive price and good quality.
2.How to start an order
After negoation and communication about the price,quantity,incoterm,etc.,you give me the order contract with stamp,then I sealed it ,send back to you,also give you the proforma invoice,you can arrange the payment according the PI.
3.What’s your payment terms
If sample,small amount: T/T in advance, ,Paypal.
If commercial order ,big amount: T/T in advance,L/C at sight.
4.Can I get a free sample
If this product is not very expensive,and you demand a small sample,we can supply free sample,but not including the shipping cost,you can provide a freight collect account or arrange the shipping cost by Paypal/Westunion.
5.What's the lead time
Generally we send out your order ASAP after payment,normally
small quanitity,3-5days.
big quanitity with stock,5-7days,
if without stock,we have to calculate the production period,then give you the lead tme.
6.How do you ship the order normally
If less than 50kg,will be shipped by express,such as FEDEX,DHL.
If above 50kg,we can ship it by air or sea
For very large quantity,ship it by sea will be the best choice.
7.How do you ensure the quality of your products
Strict QC with 6 steps testing from raw material purchase to finished product.
Meanwhile,we will responsible for the goods quality after be sold.
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