reliable manufacturers 58-61-7 for salecompectitive price Adenosine

Details:

reliable manufacturers 58-61-7 for salecompectitive price Adenosine

Adenosine USP30

Product No.: ABT-A01

CAS No.: 58-61-7
Formula: C10H13N5O4
Molecular weight: 267.24
Appearance: a white or almost white crystalline powder
Loss on drying: ≤1.0%
Assay: ≥99%
Application: API, also for production of ATP, Ara-A etc.
Storage: room temperature, tightly clsed, protected from humidity.

Package:1kg/bag, 5kg/drum, 25kg/drum 
Drum packing: Closed packing with moisture-proof plastic bag or aluminum foil bag inside, packing with carton outside.
Dimensions: 5kg drum: 30cm*30cm*30cm
                     25kg drum: 35cm*35cm*51cm

Section 1 - Chemical Product and Company Identification Product name: Adenosine CAS: 58-61-7 Company: XINXIANG AURORA BIOTECHNOLOGY CO., LTD.  2 - Composition, Information on Ingredients Hazard Symbols: None listed Risk Phrases: None listed Section 3 - Hazards Identification Potential Health Effects Eye: May cause eye irritation. Skin: May cause skin irritation. May be harmful if absorbed through the skin. Ingestion: May cause irritation of the digestive tract. May be harmful if swallowed. Inhalation: May cause respiratory tract irritation. May be harmful if inhaled. Chronic: Section 4 - First Aid Measures Eye: Flush eyes with plenty of water for at least 15 minutes, occasionally lifting the upper and lower eyelids. Get medical aid. Skin: Get medical aid. Flush skin with plenty of water for at least 15 minutes while removing contaminated clothing and shoes. Ingestion: Get medical aid. Wash mouth out with water

Mechanism of action

Its function is realized through the activation of the adenosine receptor (A receptor). Adenosine activates G protein coupled potassium channels by binding to the A receptor which makes increasing the outflow of K+ and cell membrane hyperpolarization so as to decrease the automaticity in the atrium, sinoatrial node and atrioventricular node. It can also significantly increase the level of cGMP , prolong ERP of the atrioventricular node and slowing of atrioventricular, depress sympathetic nervous or early and delayed after depolarization induced by isoproterenol and then plays an effective role in arrhythmia. This product has not been classified in I~IV anti arrhythmia medicine.

Adenosine receptor
A1 receptors, which are found in cardiomyocytes and which are responsible for the inhibition of adenylyl cylase activity which lowers cyclic adenosine monophosphate (AMP) results in sinus slowing, increase in AV node conduction delay, and antagonism of the effects of catecholamines;
A2 receptors, which are found in endothelial cells and vascular smooth muscle and are responsible for the enhancement of adenylyl cylase activity and increased cyclic AMP which relaxes smooth muscle. Both negative chronotropic and dromotropic effects of adenosine are cyclic AMP independent (direct action) as well cyclic AMP dependent (indirect action).
Chemical Properties Adenosine is an important nucleoside composed of adenine and ribose. White, crystalline, odorless powder, mild, saline, or bitter taste, quite soluble in hot water, practically insoluble in alcohol. Formed by isolation following hydrolysis of yeast nucleic acid.

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