Pam3CSK4

Pam3CSK4
Pam3CSK4
Pam3CSK4

Pam3CSK4

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1 Gram

Negotiable

  • Min.Order :1 Gram
  • Purity: ≥95%
  • Payment Terms : L/C

Keywords

Pam3-Cys-Ser-Lys-Lys-Lys-Lys (S)-[2,3-Bis(palmitoyloxy)-(2-RS)-propyl]-N-palmitoyl-(R)-Cys-(S)-Ser-(S)-Lys4-OH

Quick Details

  • Appearance:Lyophilized powder
  • Application:For research use only.
  • PackAge:5 mg
  • ProductionCapacity:1|Kilogram|Month
  • Storage:Store at 2-8°C
  • Transportation:

Superiority:

We provide customized and high-quality Pam3CSK4 product for your project.

Details:

Pam3CSK4 is a TLR 1/2 agonist and a cell-permeable, water-soluble synthetic tripalmitoylated lipopeptide that mimics the acylated amino terminus of bacterial LPs. Bacterial LPs are a family of pro-inflammatory cell wall components found in both Gram-positive and Gram-negative bacteria. Pam3CSK4 is a potent activator of the pro-inflammatory transcription factor NF-κB. It induces production of TNF-α, superoxide, NO, and IL-6, stimulates phosphorylation of p100/p110 and p60 in granulocytic-differentiated HL-60 cells, promotes differentiation of naive CD4+ T cells into Th17 cells, and enhances tyrosine protein phosphorylation and activation of ERK1/2 and MEK1/2. It is used in prevention of inflammation caused by certain bacterial infection.

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