Factory Supply Afatinib/GILOTRIF CAS 850140-72-6

Factory Supply Afatinib/GILOTRIF CAS 850140-72-6

Min.Order / FOB Price:Get Latest Price

1 Kilogram	Negotiable

1 Kilogram

Negotiable

Min.Order :1 Kilogram
Purity: 99%
Payment Terms : T/T,,MoneyGram,Other

Keywords

Afatinib GILOTRIF 850140-72-6

Quick Details

Appearance:White Powder
Application:pharmaceuticals
PackAge:1> 25kg: Packed with paper drum with double plastic bags inside. 2> 1kg: Packed with aluminium bags with ziplock bags inside.
ProductionCapacity:1000|Kilogram|Month
Storage:Cool and dry place
Transportation:Air/Sea/Express

Superiority:

Advantage

1. High quality with competitive price:
We are manufacturer and we have 2 factories in China,we can provide excellent quality products with factory price.

2. Fast and safe delivery:
1) Parcels can be sent out within 3 days after payment. Tracking number is available.
2) Secure and discreet shipment. You have various choices of transportation methods.

3. We have clients throughout the world:
1) Professional service and rich experience make customers feel at ease, adequate stock and fast delivery meet your desire.
2) Market feedback and goods feedback are appreciated, meeting customers's requirement is our responsibility.
3) High quality, competitive price, fast delivery, first-class service gain the trust and praise from the customers.

4. Exported areas: Europe , southeast Asia , the Middle East , Africa , South America and some other countries and areas.

5. We manufacture Herbal Extract and Active Pharmaceutical Ingredients products.

Business scope: Organic & Inorganic Chemicals , Pigments & Dye stuffs , Water treatment chemicals, Intermediates, Food & FEED additives and other.

Details:

High Purity Afatinib /Afatinib Powder

Name: Afatinib

CAS number: 439081-18-2

Mol. Mass: 485.937 g/mol

Density: 1.381g/cm3

Boiling Point: 676.917°C at 760 mmHg

Melting Point: 213-215°C

Flash Point: 363.186°C

Afatinib is a drug approved for the treatment non-small cell lung carcinoma(NSCLC), developed by Boehringer Ingelheim.

It acts as a angiokinase inhibitor. As of July 2012, it is undergoing Phase III clinical trials for this indication and breast cancer, as well as Phase II trials for prostate and head and neck cancer, and a Phase I glioma trial. Afatinib is a first-line treatment.

In October 2010 a Phase III trial in NSCLC patients called Lux-Lung 5 began with this drug. Fall 2010 interim results suggested the drug extended progression-free survival threefold compared to placebo, but did not extend overall survival.

In May 2012, the Phase IIb/III trial Lux-Lung 1 came to the same conclusion.

Phase II results for breast cancer that over-expresses the protein human epidermal growth factor receptor 2 (Her2-positive breast cancer) were described as promising by the authors, with 19 of 41 patients achieving benefit from afatinib. Double-blind Phase III trials are under way to confirm or refute this finding. Her2-negative breast cancers showed limited or no response to the drug.

Funcation

Like lapatinib and neratinib, afatinib is a tyrosine kinase inhibitor (TKI) that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Afatinib is not only active against EGFR mutations targeted by first generation TKIs likeerlotinib or gefitinib, but also against those not sensitive to these standard therapies. Because of its additional activity against Her2, it is being investigated for breast cancer as well as

other EGFR and Her2 driven cancers.

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