High quality CAS 53-84-9 beta-NAD Diphosphopyridine nucleotide

High quality CAS 53-84-9 beta-NAD Diphosphopyridine nucleotide

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10 Gram	FOB Price:USD 2.0000 -4.3000

10 Gram

FOB Price:USD 2.0000 -4.3000

Min.Order :10 Gram
Purity: 99%
Payment Terms : L/C|D/A|D/P|T/T|||Other

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Appearance:White powder, White Powder
Application:Animal Pharmaceuticals
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High Quality CAS 53-84-9 Beta-NAD Diphosphopyridine Nucleotide

Product Description

Product Name	Diphosphopyridine nucleotide
CAS NO.	53-84-9
MF	C21H27N7O14P2
Molecular weight	663.425
Appearance	White Powder
Purity	99% min
Melting point	140 - 142ºC
Application	Pharmaceutical intermediate

Nicotinamide adenine dinucleotide ( NAD ) is a coenzyme found in all living cells. The compound is a dinucleotide, because it consists of two nucleotides joined through theirphosphate groups. One nucleotide contains an adenine base and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms: an oxidized and reduced form abbreviated as NAD+ and NADH respectively.

Nicotinamide Adenine Dinucleotide is easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II, plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.

In addition, Nicotinamide Adenine Dinucleotide has prevention and treatment of heart block, sinus node function and anti fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atrioventricular block caused by verapamil.

Function

Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as acoenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. In addition to these metabolic functions, NAD+ emerges as an adenine nucleotide that can be released from cells spontaneously and by regulated mechanisms, and can therefore have important extracellular roles.

The enzymes that make and use NAD+ and NADH are important in both pharmacology and the research into future treatments for disease. Drug design and drug development exploits NAD+ in three ways: as a direct target of drugs, by designing enzyme inhibitors or activators based on its structure that change the activity of NAD-dependent enzymes, and by trying to inhibit NAD+biosynthesis. The coenzyme NAD+ is not itself currently used as a treatment for any disease. However, it is being studied for its potential use in the therapy of neurodegenerative diseases such asAlzheimer's and Parkinson disease. Evidence on the benefit of NAD+ in neurodegeneration is mixed; some studies in mice have produced promising results whereas a placebo-controlled clinical trial in humans failed to show any effect.

NAD+ is also a direct target of the drug isoniazid, which is used in the treatment oftuberculosis, an infection caused by
Mycobacterium tuberculosis. Isoniazid is a prodrug and once it has entered the bacteria, it is activated by a peroxidase enzyme, which oxidizes the compound into a free radical form. This radical then reacts with NADH, to produce adducts that are very potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolate reductase. In one experiment, mice given NAD for one week had improved nuclear-mitochrondrial communication.

1. Nutritional peptides enhance the assimilation of mineral elements.
2. Nucleotides develop nthe immunity and enable animals to produce more IgG and IgM.
3. Nucleotides promote intestinal and bring regeneration of benefical bacteria.
4. Nucleotides accelerate the liver recovery from damages.
5. Mannan oligosaccharides absorb pathogenic bacteria and take them out of bodies.
6. Beta-glucan activate macrophages to improve animal immunity.
7. I+G improve feed palatability and increase the intake

Application

1. Diagnostic reagents raw materials, scientific research experiments.

2. Health food, cosmetic, feed additive

3. API production

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Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

FAQ

1.Where is your sea port?

Tianjin port or other china main port

2.How about your packing?

25kg/drum or cartons or as per customers' requirement.

3.Is possible to visit your factory?

You are warm welcome to visit our factory.

4. What are your payment terms?

For the convenience of customers, we offer many kinds payment terms,it depands on product and amount.

5.After an order is placed, when to deliver?

It depends on whether the products you buy has inventory. If we have inventory, generally we can arrange

shipment after receipt of payment 2 to 3 days. If not, it will be decided by the time of the factory production.

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