Buy Sarms/Peptide CAS 2627-69-2 Aicar En Poudre Acadesine

Details:

 

Product Name: Acadesine

Alias: Aicar

MF: C9H14N4O5

CAS No: 2627-69-2

MW: 258.23

Purity: 99%

Appearance: White to off-white powder

 

Acadesine is an activator that permeates the cell membrane AMP-activatedproteinkinase (AMPK). AMPK is a key protein in metabolic regulation. When the energy supply is insufficient, the ratio of AMP/ATP increases, and AMPK will be activated to inhibit the synthesis of metabolism. AICAR activates AMPK, but does not affect the level of ATP, ADP, and AMP. At the cellular or animal level, AICAR can promote glucose uptake of skeletal muscle non-insulin dependence by activating AMPK. An AICAR induced glucose intake of skeletal muscle cannot be blocked by a PI3K inhibitor.

AICAR is a cell permeable activator of AMP-activated protein kinase(AMPK),a metabolic master regulator that is activated in times of reduced energyavailability(high cellular AMP:ATP ratios) and serves to inhibit anabolic processes. In vivo, pharmacologic activation of AMPK with AICAR mimics exercise and triggers insulins-independent glucose uptake by skeletal muscle.
Cell-permeable, allosteric activator of AMP-activated protein kinase (AMPK). Augments proliferation, differentiation and mineralization of osteoblastic MC3T3-EI cells and attenuates psychosine-induced expression of proinflammatory cytokines and iNOS in astrocytes. Promotes osteogenic differentiation of hAMSCs and BM-MSCsin vitro.

 

Function

AICAR (AICA-Riboside) strongly inhibits the transcription of PPARα and the coactivation of PPAR&alpha. In adipocyte studies it has been shown to antagonize lipolysis induced by isoprenaline and has been suggested for use in kinase cascade research. Additionally, research indicates that AICAR blocks the differentiation of 3T3-L1 (sc-2243) adipocytes. Studies demonstrate that AICAR can mimic the activity of insulin (sc-211647) by activating AMPK (AMP-activated protein kinase), and affecting the expression of PEPCK-M (PEPCK) and glucose-6-phosphatase (G6Pase). The 5-aminoimidazole-4-carboxamide ribonucleoside (ZMP) is the monophosphorylated derivative of AICA-Riboside, and it can serve as the substrate for the aminoimidazole carboxamide ribonucleotide transformylase/inosine monophosphate cyclohydrolase (ATIC).

AICAR is being clinically used to treat and protect against cardiac ischemic injury. If left untreated, it may lead to a myocardial infarct. Cardiac Ischemia is caused by insufficient blood flow and oxygen to the myocardium .The drug was first used in the 1980's as a method to preserve blood flow to the heart during surgery. Currently,the drug has also been shown as a potential treatment for diabetes by increasing the metabolic activity of tissues by changing the physical composition of muscle.

Application

(1) Applied in phamaceutical field, it is used as phamaceutical raw material to treat injuries from fall, infectious hepatitis and epidemic cerebrospinal meningitis.
(2) Applied in healthcare field, it is used in the health products to nourish brain, protect liver and improve sleep quality.
(3) Applied in comestics, it is used to promote skin metabolism and make skin more tender and firm.

 

By Express		By Air		By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods		Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed		Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

3. OEM/ODM Available.

4. Reasonable & competitive price, fast lead time.

5. Sample is available for your evaluation & Formulation development.

6. Faster delivery:Sample order in stock and 3-7 days for bulk production.

7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.

8. After-Sale Service:

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

 

 

Q1.What's your MOQ
Our MOQ is 10pcs.
Q2: How to contact with us
A: Click the Alibaba "Contact Supplier", send us message, you will get reply within 24 hours.
Q3:Which kind of payment terms do you accept
A: For small order,you can pay on Alibaba by trade assurance. For bulk order, you can pay to our company's bank account.
Q4:Can you give me a discount price
A: Sure,it depends on your quantity.
Q5:How can I get a sample
A: You can discuss with us, we normally send sample by FEDEX, DHL,EMS. A few sample is free but you need to pay for the shipping cost.
Q6: How to confirm the Product Quality before placing orders
A: You can get some sample, or we can send certificate of analysis or HPLC or NMR to you.
Q7:How can I make payment safe
A: The whole transaction is under Alibaba's (Third party) inspection.
Q8: Is it possible to custom the labels with our own design
A: Yes, just send us your artworks, you will get what you want.

Q9.Can I get the sample
Yes,we can send you the free sample after received the shipping cost(or you have forwarder,we can send to your forwarder).
Q10.Can you accept customized
Yes,we can according your require to do it.
Q11.How do I place the order
Don't worry, we are the gold supplier on Alibaba,and support Trade Assurance,after confirm the details, we will send you the payment link.