Supply Steroids CAS 107868-30-4 Bodybuilding Exemestane Aromasin Powder

Details:

Bodybuilding Oil Exemestane Aromasin-5 

CAS:	107868-30-4
MF:	C20H24O2
Application:	An antineoplastic(hormonal)
Purity:	99%

Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of

30 nM and 40 nM, respectively.Target: AromataseApproved: October 2005Exemestane competitively inhibits and

time-dependently inactivates of human placental aromatase with Ki of 4.3 nM. Exemestane displaces DHT from

rat prostate androgen receptor with IC50 of 0.9 μM . Exemestane (1 μM) increases alkaline phosphatase activity in

hFOB and Saos-2 cells and induces the expression of MYBL2, OSTM1, HOXD11, ADCYAP1R1, and glypican 2 in hFOB

cells . Exemestane causes aromatase degradation in a dose-responsive manner in MCF-7aro cells .Exemestane

increases lumbar spine BMD by 14.0% in OVX rats at dose of 100 mg/kg. Exemestane (100 mg/kg) and

17-hydroexemestane (20 mg/kg) significantly reduces an ovariectomy-induced increase in serum pyridinoline and

serum osteocalcin in rats and causes significant reductions of serum cholesterol and low-density lipoprotein

cholesterol inOVX rats .Exemestane (20 mg/kg/day s.c.) induces 26% complete (CR) and 18% partial (PR) tumor

regressions in rats with 7,12-dimethylbenzanthracene (DMBA)-induced mammary tumors .

Application & Function

Exemestane (trade name aromasin) is a drug used to treat breast cancer. it is a member of the class of drugs known as

aromatase inhibitors. some breast cancers require estrogen to grow. those cancers have estrogen receptors (ers), and

are called er-positive. they may also be called estrogen-responsive,hormonally-responsive, hormone-receptor-positive.

aromatase is an enzyme that synthesizes estrogen. aromatase inhibitors block the synthesis of estrogen. this lowers

the estrogen level, and slows the growth of cancers.

 

1. Exemestane is an oral steroidal aromatase inhibitor that is used in er-positive breast cancer in addition to surgery

and/or radiation in post-menopausal women.

 

2. It acts as a false substrate for the aromatase enzyme, and is processed to an intermediate that binds irreversibly to

the active site of the enzyme causing its inactivation, an effect also known as "suicide inhibition."

 

3. By being structurally similar to enzyme targets, exemestane permanently binds to the enzymes, preventing them

from converting androgen into estrogen

Item	Specification	Results
Appearance Identification Residue on ignition Heavy metals Water Specific optical rotation Impurity Spirooxiran 1 Spirooxiran 2 Exemestane related(compound c) Exemestane related(compound a) Any unspecified impurity Total impurity Assay(hplc) Micron	white crystalline powder ir rt (hplc) 0.1% max 10ppm max 0.5% max +290° to +300° 0.15% max 0.15% max 0.15% max 0.15% max 0.1% max 0.5% max 98% to 10.2% 100% less than 20μm	Conform Conform Conform 0.04% Conform 0.03% +290.86° Not Detected Not Detected Not Detected Not Detected 0.05% 0.25% 100.02% Conform
Conclusion: up to standard for usp pending monograph

 

 

 

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2. Dedication to quality, supply & service.

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4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

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9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

 

Delivery & Payment Terms

Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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