Supply CAS 154-17-6 2-Deoxyglucose 2-Deoxy-D-glucose 2-DG Powder

Details:

What's 2-Deoxyglucose 2-DG

	Appearance		White  crystalline powder
Molecular  formula	C6H12O5
Molecular weight	164.16
Synonyms	D-arabino-Hexose, 2-deoxy-;2-Deoxy-D-arabino-hexose;2-deoxy-d-arabino-hexos;D-Arabino-2-deoxyhexose;

 

2-deoxyglucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the

radiolabel). By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose

metabolism, which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease.

Therapeutically, 2-deoxyglucose is an investigational drug that is being studied as an anticancer and antiviral agent.

Concerning the former, 2- deoxyglucose was used as an adjunct to chemotherapy and radiotherapy in the treatment

of solid tumors (lung, breast, pancreas, head, neck, and gastric tumors).

 

Function & Application：

2-Deoxy-D-glucose is predominantly used as a diagnostic agent in its radiolabelled form (fluorine-18 is used as the

radiolabel).

By using positron emission tomography (PET), radiolabelled 2-deoxyglucose can determine glucose metabolism,

which is altered in diseases such as cardiovascular disease, tumors, and Alzheimer's disease. Therapeutically,

2-deoxyglucose is an investigational drug

that is being studied as an anticancer and antiviral agent. Concerning the former, 2- deoxyglucose was used as an

adjunct to chemotherapy and radiotherapy in the treatment of solid tumors (lung, breast, pancreas, head, neck,and

gastric tumors). The exact

mechanisms of action of 2-deoxyglucose is still being investigated, but it is known that in hypoxic cancer cells,

2-deoxyglucose is a glycolysis inhibitor that prevents ATP production and, ultimately, cell survival. With respect to

antiviral therapy, 2-deoxyglucose  was shown to be effective against herpes simplex virus by affecting the virus' ability

to penetrate cells. As an experimental drug, 2-deoxyglucose was demonstrated to work as an anticonvulsant in temporal

lobe epilepsy. In this condition, 2-deoxyglucose represses the expression of certain proteins that are at high levels

after a seizure. Although there are several possible therapeutic indications for 2-deoxyglucose presently there is no

approved indication for 2-deoxyglucose as a therapeutic agent.

 

Item	Specifications	Results
Appearance	A white or almost white crystalline powder	Conform
Heavy Metal	≤10ppm	Conform
Residue on ignition	≤0.2%	0.06%
Sulfide	≤0.05%	0.01%
Loss on drying	≤2.0%	0.95%
Assay	≥95.0%	95.8%

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

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