Supply Nootropics Products CAS 1890208-58-8 Compound 7P Powder

Details:

What's Compound 7p

CAS No.	1890208-58-8
Category	API
Quality Standard	EP/USP
MSDS	Available
COA	Contact with Effy for updated version COA.
Sample	Available
Delivery Date	In 3 days
Place Of Origin	China
Application	Pharmaceutical raw materials

Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline

in the intrinsic axon growth potential , and one of the strategies to stimulate axon growth in injured neurons involves

pharmacological manipulation of implicated signaling pathways.here we report phenotypic cell-based screen of

chemical libraries and structure-activity-guided optimization that resulted in the identification of compound 7p which

promotes neurite outgrowth of cultured primary neurons derived from the hippocampus, cerebral cortex, and retina.

in an animal model of optic nerve injury, compound 7p was shown to induce growth of gap-43 positive axons,

indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration

in vivo.further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration

in vivo will provide a rational basis for future efforts to enhance treatment strategies.

 

Raw Compound 7P powder which promotes neurite out growth of cultured primary neurons derived from the

hippocampus, cerebral cortex, and retina. in an animal model of optic nerve injury, Raw Compound 7P powder was

shown to induce growth of gap-43 positive axons, indicating that the in vitro neurite outgrowth activity of Raw

Compound 7P powder translates into stimulation of axon regeneration in vivo.further optimization of Raw Compound

7P powder and elucidation of the mechanisms by which it elicits axon regeneration in vivo will provide a rational basis

for future efforts to enhance treatment strategies.

 

Function & Application：

Compound 7p was developed as one in series of compounds with the aim of identifying dual-acting thromboxane

receptor antagonist/synthase inhibitors . In fact compound 7p shows selectivity for prostaglandin I2 synthase (PTGIS ,

CYP8A1) over thromboxane synthase (CYP5A1) .

 

Axon regeneration after injury in the central nervous system is hampered in part because if an age-dependent decline

in the intrinsic axon growth potential, and one of the strategies to stimulate axon growth in injured neurons involves

pharmacological manipulation of implicated signaling pathways .

 

Here we report phenotypic cell-based screen of chemical libraries and structure-activity-guided optimization that

resulted in the identification of compound 7p which promotes neurite outgrowth of cultured primary neurons

derived from the hippocampus, cerebral cortex, and retina .

 

In an animal model of optic nerve injury, compound 7p was shown to induce growth of GAP-43 positive axons,

indicating that the in vitro neurite outgrowth activity of compound 7p translates into stimulation of axon regeneration

in vivo. Further optimization of compound 7p and elucidation of the mechanisms by which it elicits axon regeneration

in vivo will provide a rational basis for future efforts to enhance treatment strategies .

 Increases coordination

 Improves mood

 Helps fight fatigue

 Prevents oxidation within the brain

 Treats alcohol related brain damage

Item	Standard	Test Result
Description	White crystalline powder, acid taste. freely soluble in water and alcohol, insoluble in trichloromethane and ether.	Conforms
Specific optical rotation[α]D20°	+21.3  to  +27.0°	+24.7°
State of Solution	≥98.0%	>98%
Chloride(CI)	≤0.04%	<0.04%
Ammonium(NH4)	≤0.02%	<0.02%
Sulfate(SO4)	≤0.03%	<0.03%
Heavy metals(Pb),ppm	≤ 0.001	<0.001
Loss on Drying	0.5	0.24
Residue on ignition	0.2	0.09
Assay	98.5% to 101.0%	99.6%
pH	2.0~2.8	2.57
Melting point	106 ~ 110°	108°
Iron(as Fe)	≤0.002%	<0.002%
Arsenic(As2 O3)	≤0.0001	<0.0001
	Conclusion		This batch of product complies to the standard.

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

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