Supply 99% CAS 104987-11-3 Tacrolimus Powder

Details:

What's  CAS 104987-11-3 Tacrolimus

Product Name:	Tacrolimus
CAS:	104987-11-3
MF:	C44 H69 N O12
MW:	804.02
Melting point:	113-115°C
Boiling point:	871.7±75.0 °C
Storage temp.:	−20°C

Tacrolimus, isolated from the microorganism Streptomyces tsukubaensis, is a macrolide immunosuppressant

developed by Fujisawa for organ transplantation. It displays similar but more potent immunosuppressive

activity than cyclosporin. It inhibits both cell mediated and humoral immune responses.

In animal models of organ transplantation, tacrolimus has been shown to prolong survival of hepatic,

renal, cardiac, small intestine, pancreatic and skin allografts and to reverse cardiac and renal allograft

rejection. It has been used effectively in humans as rescue or primary immunosuppressant therapy in

liver or kidney transplantation.

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Item	Analysis  Specification	Result
Description	White or almost white, crystalline power	Conform
Solubility	Freely soluble in water, soluble in ethanol (96%),sparingly soluble in acetone and in methylene chloride	Conform
Identification A	Absorption maximum at 280nm	279.4 nm
B	IR Should be identical with contrast	Conform
C	It gives reaction (a) of color	Conform
D	It gives reaction (a) of color	Conform
E	It gives reaction (a) of chlorides	Conform
Appearance of solution	The solution is clear and not more intensely colored than references solution B6 or Y6	Conform
Acidity or alkalinity	Should be conform	Conform
Related substance	Total of other impurity NMT0.25%(TLC)	Conform
Heavy metals	NMT 20 ppm	Conform
Loss on drying	NMT 0.5%	0.22%
Sulphated ash	NMT 0.2%	Conform
Residual Solvents	Should be conform	Conform
Assay(anhydrous substance)	98.0%~102.0%	99.6%
Conclusion	Conform  to  BP2007 Standard

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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