Manufacturer Supply High Purity CAS 14605-22-2 TUDCA Tauroursodeoxycholic acid

Details:

Product Name:TUDCA

CAS:14605-22-2

MF:C26H45NO6S

MW:499.7

Mol File: 14605-22-2.mol

Product Categories:Pharmaceuticals

Usage:Bear bile active ingredients, treatment of gallstones and liver disease

Tauroursodeoxycholic acid, more commonly referred to as TUDCA, is a bile salt that is found natrually occurring in the body. When regular bile salts reach the intestines, they can be metabolized by bacteria into UDCA and then later bound to a taurine molecule to become TUDCA.

TUDCA is a water-soluble bile salt, which is in contrast to regular bile salts possessing both water soluble and fat soluble ends and conferring a detergent effect. This is good for the bile salt's biological purpose (emulsifying fats in the intestines to help with absorption) but when bile acids back up in the liver, a clinical state called cholestasis which occurs when the liver is unhealthy, these bile salts can be damaging to cells by destroying the membranes and signalling for cell death. TUDCA and other water soluble bile salts like UDCA compete with this toxicity and thus indirectly protect cells from death.

Additionally, it seems that TUDCA is able to reduce stress to any cell's Endoplasmic Reticulum; an organelle in cells that serves as a highway from the nucleus out into the cytoplasm, and aids in folding proteins. Through reducing ER stress, TUDCA has been implicated in a wide range of beneficial metabolic effects such as reducing insulin resistance and diabetes, and being a neurological protection agent. However, usages of TUDCA beyond the liver are preliminary whereas usage of TUDCA for helping an already harmed liver is quite reliable as TUDCA is used in clinical settings (hospitals) for treating cholestasis.

Dosage:

10-13mg daily has once been shown to improve liver regenesis rates in a clinically ill population, and may be the lowest estimate of an active oral dose. When looking at improving bile salt composition, a dose around 15-20mg/kg bodyweight TUDCA seems best according to one study.

Benefits have been seen at 1,750mg daily for muscle and liver insulin sensitivity, which is the highest dose used for treatment of fatty liver disease.

    

Function
 

1. Cooling blood and hemostasis,clearing heat and diuresis,

2. As an effective hemostat or blood coagulant that has been used to reduce or stop hemorrhage and bleeding from internal organs, particularly controlling profuse menstruation, postpartum and uterine bleeding, and blood in the urine.

3.Treatment of high blood pressure,dysentery etc.

 

Specification

ITEM	SPECIFICATION	RESULTS
Appearance	Fine powder	Complies
Color	White	Complies
Odor&Taste	Characteristic	Complies
Assay	≥99%	99.13%
Heavy Metals	≤10ppm	Complies
Pb	≤2ppm	Complies
As	≤2ppm	Complies
Hg	≤1ppm	Complies
Cadmium	≤1ppm	Complies
Sulphates	≤300ppm	Complies
Ammonium	≤200ppm	Complies
Iron	≤10ppm	Complies
Microbiological Control
Total plate count	≤1000CFU/G	Complies
Yeast & mold	≤100 CFU /G	Complies
Total coli forms	≤100 CFU /G	Complies
E.coli	Negative	Negative
Salmonella	Negative	Negative

 

 

 

By Express		By Air		By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods		Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed		Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

3. OEM/ODM Available.

4. Reasonable & competitive price, fast lead time.

5. Sample is available for your evaluation & Formulation development.

6. Faster delivery:Sample order in stock and 3-7 days for bulk production.

7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.

8. After-Sale Service:

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

 

 

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