Manufacturer Supply CAS 53-84-9 Nicotinamide Adenine Dinucleotide Powder Nad+

Details:

Product name	Nad,NAD price,NAD china,NAD Manufacturer,NAD Supplier,NAD Factory
CAS	53-84-9
Appearance	White powder
Molecular formula	C21H27N7O14P2
MW	663.425
Purity	99%
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

Nicotinamide adenine dinucleotide (NAD) is a cofactor found in all living cells. The compound is called a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other nicotinamide. Nicotinamide adenine dinucleotide exists in two forms: an oxidized and reduced form, abbreviated as NAD+ and NADH respectively.

Nicotinamide Adenine Dinucleotide is easy to absorb oral, and can be widely distributed in the body, the excess metabolites or prototype quickly expel from urine. Nicotinamide is part of coenzyme I and coenzyme II, plays the role of hydrogen delivery in biological oxidation respiratory chain, can promote biological oxidation processes and tissue metabolism, maintain normal tissue (especially the skin, digestive tract and nervous system) integrity has an important role.
In addition, Nicotinamide Adenine Dinucleotide has prevention and treatment of heart block, sinus node function and anti fast experimental arrhythmias, nicotinamide can significantly improve the heart rate and atrioventricular block caused by verapamil.

    

Function

 

Nicotinamide adenine dinucleotide has several essential roles in metabolism. It acts as acoenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions, as a precursor of the second messenger molecule cyclic ADP-ribose, as well as acting as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins. In addition to these metabolic functions, NAD+ emerges as an adenine nucleotide that can be released from cells spontaneously and by regulated mechanisms, and can therefore have important extracellular roles.
The enzymes that make and use NAD+ and NADH are important in both pharmacology and the research into future treatments for disease. Drug design and drug development exploits NAD+ in three ways: as a direct target of drugs, by designing enzyme inhibitors or activators based on its structure that change the activity of NAD-dependent enzymes, and by trying to inhibit NAD+biosynthesis.
The coenzyme NAD+ is not itself currently used as a treatment for any disease. However, it is being studied for its potential use in the therapy of neurodegenerative diseases such asAlzheimer's and Parkinson disease. Evidence on the benefit of NAD+ in neurodegeneration is mixed; some studies in mice have produced promising results whereas a placebo-controlled clinical trial in humans failed to show any effect.
NAD+ is also a direct target of the drug isoniazid, which is used in the treatment oftuberculosis, an infection caused by Mycobacterium tuberculosis. Isoniazid is a prodrug and once it has entered the bacteria, it is activated by a peroxidase enzyme, which oxidizes the compound into a free radical form. This radical then reacts with NADH, to produce adducts that are very potent inhibitors of the enzymes enoyl-acyl carrier protein reductase, and dihydrofolate reductase. In one experiment, mice given NAD for one week had improved nuclear-mitochrondrial communication.

1. Nutritional peptides enhance the assimilation of mineral elements.
2. Nucleotides develop nthe immunity and enable animals to produce more IgG and IgM.
3. Nucleotides promote intestinal and bring regeneration of benefical bacteria.
4. Nucleotides accelerate the liver recovery from damages.
5. Mannan oligosaccharides absorb pathogenic bacteria and take them out of bodies.
6. Beta-glucan activate macrophages to improve animal immunity.
7. I+G improve feed palatability and increase the intake

8. Delay skin aging
 

Application

1. Diagnostic reagents raw materials, scientific research experiments.
2. Health food, cosmetic, feed additive
3. API production

Specification

Test	Specification	Result
Appearance	White powder	White powder
Total heavy metals	<10ppm	<4.966ppm
Arsenic	<2ppm	<0.50ppm (PQL)
Lead	<2ppm	0.086ppm
Mercury
Cadmium		0.25ppm (PQL)
Water content	<=8%	5.1%
Purity	>=98.0%	98.0%

 

 

 

By Express		By Air		By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods		Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed		Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

3. OEM/ODM Available.

4. Reasonable & competitive price, fast lead time.

5. Sample is available for your evaluation & Formulation development.

6. Faster delivery:Sample order in stock and 3-7 days for bulk production.

7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.

8. After-Sale Service:

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

 

 

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