Bulk Drug Saxagliptin Hydrate with Best Price

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                                                                                     Bulk Drug Saxagliptin Hydrate with Best Price

Saxagliptin is a anti-diabetic drug.Saxagliptin is used as monotherapy or in combination with other drugs for the treatment of Type 2 diabetes.
The synthesis of Saxagliptin by the amide coupling of N-Boc-3-hydroxyadamantylglycine and methanoprolineamide with EDC.

Saxagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor antidiabetic for the treatment of type 2 diabetes. DPP-4 inhibitors are a class of
compounds that work by affecting the action of natural hormones in the body called incretins. Incretins decrease blood sugar by increasing
consumption of sugar by the body, mainly through increasing insulin production in the pancreas, and by reducing production of sugar by the
liver. [Bristol-Myers Squibb Press Release] DPP-4 is a membrane associated peptidase which is found in many tissues, lymphocytes and
plasma. DPP-4 has two main mechanisms of action, an enzymatic function and another mechanism where DPP-4 binds adenosine deaminase,
which conveys intracellular signals via dimerization when activated. Saxagliptin forms a reversible, histidine-assisted covalent bond between
its nitrile group and the S630 hydroxyl oxygen on DPP-4. The inhibition of DPP-4 increases levels active of glucagon like peptide 1 (GLP-1),
which inhibits glucagon production from pancreatic alpha cells and increases production of insulin from pancreatic beta cells.

Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research,
development,production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has
complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has
a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with
excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict
requirements, set goals, and implement win-win development.