Supply CAS 520-27-4 Diosmin for Improving Microcirculation

Details:

What's Product Name: Diosmin
Synonyms: DIOSMETIN-7-O-RUTINOSIDE;DIOSMETIN-7-RUTINOSIDE;DIOSMIN;BAROSMIN;Diovenor;DIOSIMIN;BAROSMIN hplc;3',5-Dihydroxy-4'-methoxy-7-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavone
CAS: 520-27-4
MF: C28H32O15
MW: 608.54
EINECS: 208-289-7
Melting point: 277-278°C
Boiling point: 926.8±65.0 °C
Storage temp.: 2-8°C

Product Name	Diosmin
Synonyms:	DIOSMETIN-7-O-RUTINOSIDE;DIOSMETIN-7-RUTINOSIDE;DIOSMIN;BAROSMIN;Diovenor;DIOSIMIN;BAROSMIN hplc;3',5-Dihydroxy-4'-methoxy-7-(6-O-α-L-rhamnopyranosyl-β-D-glucopyranosyloxy)flavone
CAS:	520-27-4
MF:	C28H32O15
MW:	608.54
EINECS:	208-289-7
Melting point:	277-278°C
Boiling point:	926.8±65.0 °C

Diosmin is also called Alvenor. It is a kind of drug for the treatment of hemorrhoid symptoms related to

acute episodes, can also be used in the treatment of symptoms associated with venous lymphatic

insufficiency (leg heavy, pain, morning acid swells discomfort).
The effects of diosmin are as below:

1, Has specific affinity to the venous system, enhance the tension system without affecting the artery of

vein;

2, To the microcirculation system, decrease the blood viscosity, improve the velocity of reducing silt up;

3, Contract the lymphatic system, which can enhance lymphatic and lymph drainage speed, speed up

the return relieve edema.

4, Commercially available diosmin uses micronization technology, increase the contact area after using

medicine, absorb more and higher bioavailability. Suitable for all kinds of hemorrhoids and acute

hemorrhoids, also can be used for the treatment of chronic venous insufficiency, such as varicose veins,

leg ulcers, etc.

 

 

Application & Function

Diosmin is a nutrient that is widely contained in citrus and that has been indicated to improve glucose

metabolism in diabetic disorders. Recently, we demonstrated that diosmin induces β-endorphin to lower

hyperglycemia in diabetic rats. However, the mechanisms of diosmin in opioid secretion were unclear.

Therefore, we focused on the secretion of opioids from isolated adrenal glands induced by diosmin.

The changes in the released β-endorphin-like immunoreactivity (BER) were determined using ELISA.

Diosmin increased the BER level in a dose-dependent manner, and this effect was markedly reduced

in the absence of calcium ions. Activation of the imidazoline I-2 receptor (I-2R) has been introduced

to induce opioid secretion. Interestingly, we observed that diosmin activates CHO cells expressing I-R. 

Used in food, medicine, health products, etc Action mechanism:

1.Enhance the vein tension, even not exceptional under high temperature condition. It has a stronger

effect causing the constriction of vein than other drugs such as rutin, still can enhance the tension of

the vein when the body was acidosis. Diosmin has specific affinity for vein without affecting the arterial

system.

2. Improve microcirculation. Diosmin can obviously reduce the white blood cells and vascular endothelial

cell adhesion, migration, disintegrating the release of inflammatory substances, such as histamine,

slow excitation peptide, complement, leukotriene, prostaglandins, and too many free radicals, reducing

the permeability of capillaries and enhance its tension. Diosmin can lower blood viscosity, enhance the

function of red blood cell velocity, thus reduce the microcirculation clogged.

3. Promote lymphatic circumfluence. Diosmin can increase the speed of lymphatic drainage.

 

Product	Diosmin
Appearance	Hygroscopic Powder
Color	Grayish yellow or light yellow
Molecular Weight	608.54
CAS NO.	520-27-4
Molecular Formula	C28H32O15
Country of Origin	China
Certificate	CEP, KOSHER, ISO9001, ISO22000
Test Specifications	TS-10017-00/Ph.Eur. 8.3
Solubility	Practically insoluble in water, soluble in dimethyl sulfoxide, practically insoluble in ethanol (96%). It dissolves in dilute solutions of alkali hydroxides
Iodine	≤0.1%
Solution NaOH 1N	≤0.3
Density	≥0.5 g/ml
Related Substances (HPLC)	Impurity A(Acetoisovanillone)	≤0.5%
	Impurity B (Hesperidin)	≤4.0%
	Impurity C (Isorhoifolin)	≤3.0%
	Impurity D (6-iodo-diosmin)	≤0.6%
	Impurity E(Linarin)	≤3.0%
	Impurity F (Diosmetin)	≤2.0%
	Unspecified Impurities	≤0.4%
	Total impurities	≤8.5%
Heavy metalsnts	≤20ppm
Particle size	Micronized (95% < 5microns)
Water	≤6.0%
Assay on anhydrous basis	90.0%~102.0%
Packing	25kg
Production Capacity	10MT/Month

 

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

7. Faster delivery:Sample order in stock and 3-7 days for bulk production.

8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder

9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

 

Delivery & Payment Terms

Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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