Supply CAS 57808-66-9 Domperidone Powder

Details:

What's Domperidone Powder

Product Name	Domperidone
Cas No	57808-66-9
Appearance	White Powder
MF	C22H24ClN5O2
MW	425.911

Domperidone is a peripherally selective dopamine D2receptor antagonist developed by Janssen

Pharmaceutica that is used as an antiemetic, gastroprokinetic agent, and galactogogue.It may be

administered orally or rectally, and is available in the form of tablets,orally disintegrating tablets

(based on Zydis technology), suspension, and suppositories.The drug is used to relieve nausea and

vomiting; to increase the transit of food through the stomach (by increasinggastrointestinal peristalsis);

and to promote lactation (breast milk production) by release of prolactin.

 

Application & Function 

Nausea and vomiting
There is some evidence that domperidone has antiemetic activity.It is recommended in the Canadian

Headache Society's guidelines for treatment of nausea associated with acute migraine.

Gastroparesis
Gastroparesis is a medical condition characterised by delayed emptying of the stomach when there is no

mechanical gastric outlet obstruction. Its cause is most commonly idiopathic, a diabetic complication or

a result of abdominal surgery. The condition causes nausea, vomiting, fullness after eating, early satiety

(feeling full before the meal is finished), abdominal pain and bloating.

Domperidone may be useful in diabetic and idiopathic gastroparesis.
However, increased rate of gastric emptying induced by drugs like domperidone does not always correlate

(equate) well with relief of symptoms.

Parkinson's disease
Parkinson's disease is a chronic neurological condition where a decrease in dopamine in the brain leads

to rigidity (stiffness of movement), tremor and other symptoms and signs. Poor gastrointestinal function,

nausea and vomiting is a major problem for people with Parkinson's disease because most medications

used to treat Parkinson's disease are given by mouth. These medications, such as levodopa can cause

nausea as a side effect. Furthermore, anti-nausea drugs, such as metoclopramide, which do cross the

blood-brain barrier may worsen theextra-pyramidal symptoms of Parkinson's disease.

Domperidone can be used to relieve gastrointestinal symptoms in Parkinson's disease, because, even

though it blocks dopamine receptors (which would be expected to worsen Parkinson's disease), it does

not cross theblood-brain barrier (the barrier between the blood circulation of the brain and the rest of

the body).In addition to this, domperidone may enhance the bioavailability (effect) of levodopa (one

of the main treatments in Parkinson's disease).
Although these features make domperidone a useful drug in Parkinson's disease, caution is needed

due to thecardiotoxic side effects of domperidone especially when given intravenously, in elderly

people and in high doses (> 30 mg per day). A clinical sign of domperidone's potential toxicity

to the heart is the prolongation (lengthening) of the QT interval (a segment of the heart's electrical

pattern).

Functional dyspepsia
Domperidone may be used in functional dyspepsia in both adults and children

 

Items	Requirements	Results
Appearance	White to off white powder	White powder
Solubility	Practically insoluble in water, soluble in dimethylformamide,	Confirms
	slightly soluble in ethanol(96%) and in methanol
Identification	A. M.P. 244~248ºC	244.5~245.5ºC
	B. IR should comply	Confirms
	C. TLC should comply	Confirms
	D. It gives the reaction of non-nitrogen substituted barbiturates.	Confirms
Clarity of solution	The solution is clear and not more intensely colored than	Confirms
	reference solution Y6
Related substance	Total impurities≤0.5%	≤0.29%
	Individual impurity≤0.25%	≤0.18%
Loss on drying	≤0.5%	0.07%
Sulphated ash	≤0.1%	≤0.05%
Heavy metal	≤20ppm	<20ppm
Assay	99.0%~101.0%	99.49

 

 

 

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2. Dedication to quality, supply & service.

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6. Sample is available for your evaluation & Formulation development.

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2) 30 Days Warranty of quality of goods. 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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