Supply Antifungal Drugs CAS 22832-87-7 Miconazole Nitrate Powder

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What's CAS 22832-87-7 Miconazole Nitrate

CAS.No	22832-87-7
Product name	Miconazole nitrate
MF	C18H15Cl4N3O4
MW	479.14
EINECS	245-256-6

miconazole nitrate is also called daknin, he's forest, miconazole, miconazole, miconazole, miconazole,

synthetic 1- benzene ethyl imidazole derivatives are imidazole broad-spectrum antifungal agents is a

common drug for the treatment of skin tinea, no hormones, no side effects, the the main active ingredient

for miconazole. miconazole nitrate is rarely used in china now. its antibacterial spectrum, antibacterial

activity and mechanism of action are similar to clotrimazole. it can be used as an alternative to amphotericin

b in the treatment of deep fungal infections. it is suitable for the treatment of systemic and disseminated

infections caused by cryptococcus neoformans and candida albicans. oral absorption effect is poor, after

local medication mainly stay in the lesion site, absorbed into the body very little. in vivo distribution in the

body and the liquid, can penetrate into the joint, and peritoneal inflammation in the vitreous body, but in

the sputum, saliva in low concentration of blood cerebrospinal fluid barrier penetration is poor, not easily

through the blood-brain barrier. the binding rate of plasma protein was 90%. metabolic inactivation

through liver is an inactive metabolite.

miconazole nitrate is an antifungal drug, the drug is daktarin we are familiar with the commonly used in

the treatment of skin tinea, by inhibiting the biosynthesis of the fungal cell membrane components of

ergosterol, destroy the structure of cell membrane, the cell membrane permeability increased, resulting

in the leakage of intracellular components and inhibit glucose, prevent nutrient intake, eventually fungal

cell death, suitable for the treatment of tinea corporis, tinea cruris, tinea manus, tinea pedis, tinea versicolor

and fungal paronychia and by yeast (such as candida) caused by gram positive bacteria and vaginal infection

and secondary infection, external ear infections, bacterial skin infections are effective.

 

 

Test Items			Specification	Test Results
Appearance			White or Almost white powder	Complies
Identification		IR	Similar to standard	Complies
Appearance of Solution			The solution is clear and not more intensely cloured than reference solutions	Complies
Solubility			Very slightly soluble in water; soluble in meth anol ; slightly soluble in alcohol	Complies
Angle of optical rotation			-0.1o~+0.1o	Complies
Related Substances	Each Impurity		≤0.25%	0.18%
	Total Impurity		≤0.5%	0.25%
Melting Point			163~167ºC	164.5ºC
Loss on Drying			≤0.5%	0.32%
Residue on Ignition			≤0.1%	0.01%
Assay (on dry basis)			98.0~102.0%	99.38%

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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