Supply APIs 99% CAS 78628-80-5 Terbinafine Hydrochloride Fungal Infection Treatment

Details:

What's Terbinafine Hydrochloride Raw Powder

Product Name	Terbinafine hydrochloride
CAS	78628-80-5
Appearance	White or almost white crystalline powder
MF	C21H26ClN
Molecular Weight	327.89
Purity	99% min
Storage	Keep in a cool, dry, dark location in a tightly sealed container or cylinder
Shelf Life	24 Months

 

Terbinafine hydrochloride is an antifungal, which is highly hydrophobic and tends to accumulate in hair,

skin, nails, and fatty tissue.

 

Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and

dichloromethane, soluble in ethanol, and slightly soluble in water.

Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an

enzyme that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents

conversion of squalene to lanosterol, ergosterol cannot be synthesize.

 

 

Application & Function

^{Terbinafine hydrochloride is an antifungal, which is highly hydrophobic and tends to accumulate in hair,}

^{skin, nails, and fatty tissue.}

 

^{Terbinafine hydrochloride is a white fine crystalline powder that is freely soluble in methanol and}

^{dichloromethane, soluble in ethanol, and slightly soluble in water.}

 

^{Like other allylamines, terbinafine inhibits ergosterol synthesis by inhibiting squalene epoxidase, an enzyme}

^{that is part of the fungal cell membrane synthesis pathway. Because terbinafine prevents conversion of}

^{squalene to lanosterol, ergosterol cannot be synthesize.}

 

^{1. Terbinafine is mainly effective on the dermatophyte group of fungi.}

 

^{2. As a 1% cream or powder, it is used topically for superficial skin infections such as jock itch (tinea cruris),}

^{athlete's foot (tinea pedis), and other types of ringworm (tinea corporis). Terbinafine cream works in about}

^{half the time required by other antifungals.}

^{3. Oral 250-mg tablets are often prescribed for the treatment of onychomycosis, a fungal nail infection,}

^{typically by a dermatophyte or Candida species. Fungal nail infections are located deep under the nail in}

^{the cuticle to which topically applied treatments are unable to penetrate in sufficient amounts.}

^{The tablets may, rarely, cause hepatotoxicity, so patients are warned of this and may be monitored with}

^{liver function tests. Alternatives to oral administration have been studied.} 

^{4. Terbinafine hydrochloride may induce or exacerbate subacute cutaneous lupus erythematosus. Persons}

^{with lupus erythematosus should first discuss possible risks with their doctor before initiation of therapy.}

 

Items	Specification	Results
Appearance	White or similar white powder, soluble in anhydrous ethanol and methanol, slightly soluble in acetone, extremely soluble in water	Conforms
Identify	Comply with the standard	Conforms
Impurity B	≤0.15%	0.001%
Impurity E	≤0.05%	0.001%
Unknown single impurity	≤0.1%	0.03%
Total impurity	≤0.3%	0.1%
sulphated ash	≤0.1%	0.05%
Loss on dry	≤0.5%	0.2%
ignition residue	≤0.1%	0.021%
residual solvent	isopropanol≤5000ppm;ethyl acetate≤5000ppm;trichloromethane≤60ppm	Isopropanol 5ppm;ethyl acetate 101ppm;trichloromethane not detected
Assay	99-101%	99.7%

 

 

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2. Dedication to quality, supply & service.

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4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

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2) 30 Days Warranty of quality of goods. 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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