Supply 99% Mosapride Citrate Dihydrate CAS 156925-25-6 Mosapride Citrate for Promoting Digestion

Details:

What's Mosapride Citrate Dihydrate

Name	Mosapride citrate, CAS 156925-25-6
Other name	Mosapride citrate 156925-25-6 Gasmot AS-4370 Mosapride (citrate) Gasmotin TAK-370 AS 4370 4-amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)morpholin-2-yl)methyl)benzamide 2-hydroxypropane-1,2,3-tricarboxylate (+-)-4-Amino-5-chloro-2-ethoxy-N-((4-(4-fluorobenzyl)-2-morpholinyl)methyl)benzamide citrate
CAS NO.	156925-25-6
Molecular Formula	C27H37ClFN3O12
Molecular Weight	421.893

 

Citrate moser will benefit (Mosapride Citrate, MC) promote power for the fourth generation of

gastrointestinal medicine, is a potent selectivity of 5 - HT4 agonists, through 5 - excited myenteric plexus

HT4 receptors, stimulate acetylcholine release, strengthen the stomach and duodenum movement, clinical

used in functional dyspepsia, gastroesophageal reflux disease, diabetic gastroparesis, partial nephrectomy

in patients with gastric diseases such as gastric dysfunction. Common adverse reactions include diarrhea,

abdominal pain, dry mouth, rash, tiredness and headache. At present, its market products are only tablets,

dispersible tablets, capsules and other oral dosage forms.

Moxapride citrate is similar to cisapride, both of which are benzodiamide derivatives. By stimulating 5-ht4

receptors in intestinal muscle plexus, moxapride citrate can increase the release of acetylcholine in nerve

endings and promote gastrointestinal motility and gastric empty.it has the advantages of strong receptor

selectivity, good pharmacokinetics, selective action on digestive tract and small dose. Electrophysiological

studies have shown that it has no effect on extending the action potential duration of isolated ventricular

muscle and bradycardia fibers, so it has better safety.

 

 

Application & Function

Citrate moser will benefit (Mosapride Citrate, MC) promote power for the fourth generation of

gastrointestinal medicine, is a potent selectivity of 5 - HT4 agonists, through 5 - excited myenteric plexus

HT4 receptors, stimulate acetylcholine release, strengthen the stomach and duodenum movement, clinical

used in functional dyspepsia, gastroesophageal reflux disease, diabetic gastroparesis, partial nephrectomy

in patients with gastric diseases such as gastric dysfunction. Common adverse reactions include diarrhea,

abdominal pain, dry mouth, rash, tiredness and headache. At present, its market products are only tablets,

dispersible tablets, capsules and other oral dosage forms.

Moxapride citrate is similar to cisapride, both of which are benzodiamide derivatives. By stimulating 5-ht4

receptors in intestinal muscle plexus, moxapride citrate can increase the release of acetylcholine in nerve

endings and promote gastrointestinal motility and gastric empty.it has the advantages of strong receptor

selectivity, good pharmacokinetics, selective action on digestive tract and small dose. Electrophysiological

studies have shown that it has no effect on extending the action potential duration of isolated ventricular

muscle and bradycardia fibers, so it has better safety.

 

Test	Specification	Result
Appearance	White or almost white crystalline powder, ordourless	Almost white crystalline powder
Solubility	Slightly soluble soluble in in glacial ethnoal acid , practically soluble in water or trichloromethane, freely Slightly soluble soluble in in glacial ethnoal acid ,	Conforms
Identification	Color reaction: adds a few potassium hypermanganate, shaking out, then purple disappear;	Conforms
	Then becomes yellow to red or purple solution	Conforms
	Fluoride identification: Then shows boluish violet.	Conforms
	UV absorption: the maximum absorption wave length should be at 273±2nm, 308±2nm, the minimum absorption wave length should be at 209±2nm	Conforms
	IR: Both spectra exhibit similar intensities of absorption at the same wave numbers.	Conforms
Fluoride	2.6%-3.2%( on the anhydrous basis)	3.0%
Water	5.3%-6. 5%	5.6%
Residue on ignition	NMT 0.1%	0.06%
Heavy metals	NMT20ppm	Conforms
chloride	NMT 0.01%	Conforms
Related substance	Total impurities: NMT 0.5%	0. 041%
Residual solvents	Methonal NMT 3000ppm	100 ppm
	Dichlormethane: NMT 600ppm	undetectable
	N,N-dimethylformamide: NMT 880ppm	undetectable
	Chloroform: NMT 60ppm	undetectable
Assay	NLT 98.5% (on the anhydrous basis)	100.8%
Conclusion	Conforms to the requirements of in-house standard.

 

 

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4. OEM/ODM Available.

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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