Supply 99% CAS 23593-75-1 Clotrimazole Powder

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What's  CAS 23593-75-1 Clotrimazole Powder

Product Name	Clotrimazole
CAS NO.	23593-75-1
MOQ	1 kg
Other Name	Clotrimazole crystalline,Clotrimazole powder
Molecular Formular	C22H17ClN2
Molecular Weight	344.837
Appearance	White crystalline powder

Clotrimazole is an  derivative, an antifungal compound and is a CYP (cytochrome P450) inhibitor.

Target: Antifungal; CYPClotrimazole  is an antifungal medication commonly used in the treatment of fungal

infections (of both humans and other animals) such as vaginal yeast infections, oral thrush, and ringworm.

It is also used to treat athlete's foot and jock itch.It is commonly available as an over-the-counter substance

in various dosage forms, such as a cream, and also (especially in the case of ear infection) as a combination

medicine. It is also available as a troche or throat lozenge (prescription only). For ear infection, it is often

applied in liquid form, as ear drops.The antimycotic drug clotrimazole inhibits the function of the gastric

H,K-ATPase in a manner similar to that observed for the Na,K-ATPase. Because of the high hydrophobicity

of the compound, the interaction between clotrimazole and the ion pump occurs at the membrane domain

in the apolar core of the membrane. The enzymatic activity was inhibited with a half-saturating concentration

of 5.2 microM. Various partial reactions of the pump cycle were analyzed with the electrochromic styryl

dye RH421 that has been widely used to study the transport mechanism of P-type ATPases.

 

Application & Function

1. Clotrimazole inhibits ergosterol biosynthesis by interfering with cytochrome P450 activity;

 

2. Damage the fungal cell membrane and change its permeability to avoid the leakage of important substances

in the cell;

 

3. It can also inhibit the biosynthesis of triglycerides and phospholipids in fungi;

 

4. The product can also inhibit the activities of oxidation and peroxidase, cause excessive accumulation

of peroxides in cells and cause degeneration and necrosis of fungal subcellular structure.

 

5. Clotrimazole has broad-spectrum antifungal activity. It has good antibacterial activity against dermatophytes,

Trichophyton, Aspergillus, chromomyces, Cryptococcus and Candida. It also has certain antibacterial activity

against Sporothrix schenckii, Blastomyces dermatitis, coccidiospora and histoplasmosis.

 

ITEMS	SPECIFICATION EP6/USP32	RESULTS
CHARACTERS(PH.EUR.)	A WHITE OR ALMOST WHITE,CRYSTALLINE POWDER	COMPLIES
SOLUBILITY(PH.EUR.)	PRACTICALLY INSOLUBLE IN WATER,SPARINGLY SOLUBLE IN ACETONE AND IN ALCOHOL,SLIGHTLY IN METHYLENE CHLORIDE	COMPLIES
IDENTIFICATION
A.IR-SPECTRUM(PH.EUR)	MEETS THE REQUIREMENT	COMPLIES
B.TLC(PH.EUR)	MEETS THE REQUIREMENT	COMPLIES
A.IR-SPECTRUM(USP)	MEETS THE REQUIREMENT	COMPLIES
B.UV ABSORPTION(USP)	MEETS THE REQUIREMENT	COMPLIES
SPECIFIC OPTICAL ROTATION
(PH.EUR)	BETWEEN+150°AND +156°	+152.1°
(USP)	BETWEEN+150°AND +156°	+153.3°
LOSS ON DRYING
(PH.EUR)	NOT MORE THAN 1.0%	0.04%
(USP)	NOT MORE THAN 1.0%	0.05%
RESIDUE ON IGNITION(USP)	NEGLIGIBLE,FROM 100MG	COMPLIES
RELATED SUBSTANCES(PH.EUR)
ANY INDIVIDUAL IMPURITY	NOT MORE THAN 0.5%	0.30%
SUM OF IMPURITIES	NOT MORE THAN 1.5%	1.24%
CHROMATOGRAPHIC PURITY(USP)
ANY INDIVIDUAL IMPURITY	NOT MORE THAN 0.5%	0.28%
SUM OF IMPURITIES	NOT MORE THAN 2.0%	1.25%
ASSAY
UV ABSORPTION(PH.EUR.)	BETWEEN 97.0% AND 103.0%	100.70%
HPLC(USP)	BETWEEN 97.0% AND 102.0%	98.70%
RESIDUAL SOLVENT(IN-HOUSE)
METHANOL	NOT MORE THAN 500PPM	NOT DETECT OUT
ETHANOL	NOT MORE THAN 2000PPM	455PPM
METHYLENE CHLORIDE	NOT MORE THAN 600PPM	NOT DETECT OUT
CONCLUSION:THE PRODUCT CONFORMS TO PH.EUR.6/USP34

 

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

7. Faster delivery:Sample order in stock and 3-7 days for bulk production.

8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder

9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

 

Delivery & Payment Terms

Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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