Manufacturer Supply High Purity API CAS 57808-66-9 Domperidone for Antiemetic

Details:

Product Name: Domperidone
CasNo: 57808-66-9
Molecular Formula: C22H24ClN5O2
Appearance: White powder
Application: Pharmaceutical Intermediate
DeliveryTime: With about 7-10 days after receipt 
Package: as you requested
Port: China main port
Purity: 99%
Storage: room temperature
Transportation: by courier, by sea
Grade: Industrial Grade,Pharma Grade

Domperidone is a peripherally selective dopamine D2receptor antagonist developed by Janssen Pharmaceutica that is used as an antiemetic, gastroprokinetic agent, and galactogogue.It may be administered orally or rectally, and is available in the form of tablets,orally disintegrating tablets (based on Zydis technology), suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasinggastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.

    

Function
 

Gastrointestinal problems
There is some evidence that domperidone has antiemetic activity. Domperidone is used, together with metoclopramide, cyclizine, and 5HT3 receptor antagonists (such as granisetron) in the treatment of nausea and vomiting.
It can be used in patients with Parkinson's disease because, unlike metoclopramide, domperidone does not cross the blood-brain barrier.
Domperidone has also been found effective in the treatment of gastroparesis, a stomach motility condition, and for paediatric gastroesophageal reflux (infant vomiting).
In Canada, the drug is indicated "for the symptomatic management of upper gastrointestinal motility disorders associated with chronic and subacute gastritis and diabetic gastroparesis." The drug may also be used "to prevent gastrointestinal symptoms associated with the use of dopamine agonist antiparkinsonian agents".

Application

Domperidone is a peripherally selective dopamine D2receptor antagonist developed by Janssen Pharmaceutica that is used as an antiemetic, gastroprokinetic agent, and galactogogue.It may be administered orally or rectally, and is available in the form of tablets,orally disintegrating tablets (based on Zydis technology), suspension, and suppositories.The drug is used to relieve nausea and vomiting; to increase the transit of food through the stomach (by increasinggastrointestinal peristalsis); and to promote lactation (breast milk production) by release of prolactin.

Specification
 

Items	Requirements	Results
Appearance	White to off white powder	White powder
Solubility	Practically insoluble in water, soluble in dimethylformamide,  slightly soluble in ethanol(96%) and in me thanol	Confirms
Identification	A. M.P. 244~248ºC	244.5~245.5ºC
	B. IR should comply	Confirms
	C. TLC should comply	Confirms
	D. It gives the reaction of non-nitrogen substituted barbiturates.	Confirms
Clarity of solution	The solution is clear and not more intensely colored than reference solution Y6	Confirms
Related substance	Total impurities≤0.5%	≤0.29%
	Individual impurity≤0.25%	≤0.18%
Loss on drying	≤0.5%	0.07%
Sulphated ash	≤0.1%	≤0.05%
Heavy metal	≤20ppm	<20ppm
Assay	99.0%~101.0%	99.49%
Conclusion: This product conforms to the EP7.0 detection.

 

By Express		By Air		By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods		Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed		Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

3. OEM/ODM Available.

4. Reasonable & competitive price, fast lead time.

5. Sample is available for your evaluation & Formulation development.

6. Faster delivery:Sample order in stock and 3-7 days for bulk production.

7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.

8. After-Sale Service:

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

 

 

Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount
A: Yes, for larger quantity, we always support with better price. 

Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests
Q: How to start orders or make payments
A: You can send our your Purchase order (if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.