China Supplier Supply Fip Treatment GS-441 2.5ml/vial 5ml/vial?Free Shipping to Europe CAS 1191237-69-0

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                                        China Supplier Supply Fip Treatment GS-441 2.5ml/vial 5ml/vial Free Shipping to Europe CAS 1191237-69-0

Product Name	GS-441524 Injection
Synonyms	GS-441524
CAS	1191237-69-0
Appearance	Clear colorless liquid
Assay	15-17.5mg/ml
Packing	2.5ml/vial; 5ml/vial

GS-441524 is a small molecule nucleoside analog that acts as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA
polymerase; strongly inhibits feline infectious peritonitis virus (FIPV) in tissue culture and experimental cat infection studies, effectively inhibits
FIPV replication in cultured CRFK cells and in naturally infected feline peritoneal.

How GS441524 Cures FIP

If a cat's immune system is healthy and mature, the white blood cells should fight off an infection or virus, and allow the
cat to build up an immune response, or antibodies.  Cats who develop FIP have an immune defect or deficiency that causes
the white blood cells to replicate, rather than fight, the virus. Essentially, the cats immune system is spreading the virus
throughout the cat's body rather than trying to eliminate it.  Cats who have no immune response develop wet FIP, while
cats who have a partial immune response develop dry FIP. 

The nucleoside analog GS-441524 is a molecular precursor to a pharmacologically active nucleoside triphosphate mo
-lecule. These analogs act as an alternative substrate and RNA-chain terminator of viral RNA dependent RNA polyme
-rase.  In layman's terms, GS441 interjects itself into the chain reaction and stops the replication of the virus.  

Course of GS441 Treatment

Dr Pedersen's case study determined that a successful course of treatment with GS441 is 12 weeks, administered daily. 
Some owners have stopped treating once blood work and diagnostics returned to normal;
however, the few cats who did relapse were among those who stopped prior to the 12 week protocol. 
Because the course of treatment is both emotionally and financially taxing, most owners currently using GS opt to pursue the
full 12 weeks, to ensure the highest probability of success.  Cats who undergo the full 12 weeks and remain symptom-free for
90 days following conclusion of treatment are officially cured of FIP.  

GS441 comes in both injectable form, and as of June 2019, a pill form. 
Both are administered daily and the dose is based on the weight of the cat. 

For wet & dry FIP without neurological or ocular symptoms, the recommended dosage is 5mg (GS) x weight (kg) / GS
concentration per 1mL = dose per 24 hr.   
Neurological and Ocular FIP cats require 7mg/kg MINIMUM, and can go as high as 10mg/kg for extreme ocular or
neurological cases.

A dosing calculator can be found here.

It is important to note that the dosage should not be reduced during the course of treatment, regardless of how well the cat is
responding.  Conversely, if the cat is not responding to the starting dosage, it is safe to increase. It is also crucial to check the
cat's weight often, and adjust the daily dose accordingly. 

The only known side effect of GS441 is skin lesions or burns, due to the acidity of the solution (injectable form). For this
reason, it is recommended to always clean the cat's skin after giving an injection.  Many owners also opt to give or Hemp
oil 30-60 minutes before injecting, to help minimize the stress.  Should you opt to do this, it is critical that the product be
veterinary grade and the proper dose should be determined by a veterinarian.   hemp oil can be fatal to a cat if not administered
properly.  More commonly, Gabapentin, a mild pain medication can be given orally 60-90 minutes prior to the injection.
The vast majority of cats using GS tolerate the injections just fine without the need for any pain medication or sedative.  

Supportive Care

While we've seen first hand that GS is a miracle drug, it's not the end-all-be-all. 
You still need to support your cat's well-being while waiting for GS to arrive and until your cat starts to respond to it. 
Proper supportive care can make all the difference as to whether or not the cat survives.
Lack of proper supportive care can cause further complications, up to and including death. 

Cats need to consume minimally 200 calories per day and 60 ml of water per day.
Anemia needs to be treated, whether via B12 or possibly a transfusion, depending on severity. 
Fluids may need to be drained. Fevers need to be monitored and reduced.  
For additional information about crucial home care and supportive care of FIP cats, please continue here.  

Supplemental Care When Using GS441 to Cure FIP

In general, unless the cat has a secondary or underlying condition besides FIP, all prescription medications can be stopped
once treatment with GS begins.  However, all cats, FIP or not, can benefit from a high quality probiotic such as Fortiflora.
A healthy gut is essential in fighting FIP and can help stave off so many other illnesses too.   

For additional information on overall wellness and support, please view the vitamins and supplements page.  

Palliative Care For Cats With FIP

We understand that there are many reasons why someone may not want to use GS441.  While it is highly effective,
it is also still experimental and in many circumstances, cost prohibitive.  

For those who wish to provide palliative treatment to their FIP cat, there are several options available. 

teroid Treatment for FIP

For many years, steroid treatment was the only option for FIP cats.  It is entirely palliative in nature, i.e. it's purpose is to keep the
cat comfortable for however much time he/she has left.  

Steroids are inexpensive and can help provide temporary comfort to an FIP cat by increasing appetite, reducing fever, reducing
inflammation, and with wet FIP, steroids may also help to reduce the effusion.

Home Care/Supportive Care

The success of palliative care, as well as your cat's quality of life, depends highly on supportive care and treating symptoms such
as inappetence, fever, anemia, diarrhea and more.  Please continue reading about supportive care here. 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development,
production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental
facilities. And advanced testing instruments ensure the stability of  product quality from all aspects. The company has a complete sales service system,
the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements,
set goals, and implement win-win development.

By Express	By Air	By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods	Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed	Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

7. Faster delivery:Sample order in stock and 3-7 days for bulk production.

8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder

9. After-Sale Service:

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

Q1: Can i get some samples  
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western
Union or Paypal or Escrow.

Q3: How to confirm the Product Quality before placing orders
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the
samples.You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What's your MOQ
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery leadtime
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6:Is there a discount
A:Different quantity has different discount.

Q7: How do you treat quality complaint
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us,
we will send you free goods for replacement or refund your loss.