Supply Antiallergic 99% CAS 53902-12-8 Tranilast Powder

Details:

What's Tranilast Powder

Product Name:	Tranilast
Synonyms:	2-((3-(3,4-dimethoxyphenyl)-1-oxo-2-propenyl)amino)-benzoicaci;n-(3,4-dimethoxycinnamoyl)-anthranilicaci;n-5';rizaben;SB-252218;N-(3',4'-DIMETHOXYCINNAMOYL)ANTHRANILIC ACID;Tranilast - CAS 53902-12-8 - Calbiochem;2-[[3-(3,4-DIMETHOXYPHENYL)-1-OXO-2-PROPENYL]AMINO] BENZOIC ACID
CAS No.:	53902-12-8
Formula:	C18H17NO5
Molecular weight:	327.33
Appearance:	white crystalline powder

Tranilast is a compound that exhibits anti-inflammatory and immunomodulatory effects by inhibiting lipid

mediator and cytokine release from inflammatory cells and interfering with PDGF- and TGF-β1-induced

proliferation and migration of vascular medial smooth muscle cells. Tranilast suppresses production of

prostaglandin D2 (IC50 = 0.1 mM), prostaglandin E2 (IC50 = ~1-20 μM), thromboxane B2 (IC50 = ~10-50 μM),

TGF-β1 (IC50 = ~100-200 μM), and interleukin-8 (IC50 = ~100 μM) in in vitro models as well as attenuates

of the proinflammatory activity of human monocytes. While originally marketed as an antiallergenic drug,

the efficacy of tranilast in preventing restenosis after percutaneous coronary intervention has been tested

in a large-scale clinical trial.

Additionally, tranilast inhibits VEGF-induced angiogenetic activities (i.e., proliferation, migration and tube

formation of vascular endothelial cells) with IC50 values of 22, 18 and 193 μM, which may prove

therapeutic for various retinal diseases.

 

Items	Specification
Appearance	Light yellow or light-yellow green crystal or crystalline powder
Assay	≥98.5%
Melting point	207-210°C
Identification:	1)It appears positive reaction 2)Maximum absorbability at 333nm Wavelength Minimum absorbability at 263nm Wavelength 3)Complies
Chloride	Conform
Relevant material	Conform
Loss on drying	≤0.5%
Residue on ignition	≤0.1%
Heavy metals	≤15ppm
Microbe limitation	Conform

 

 

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2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

7. Faster delivery:Sample order in stock and 3-7 days for bulk production.

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9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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