Pharmaceutical Manufacturing Bulk Raw Material 99% CAS 439081-18-2 Afatinib/ Bibw 2992 Powder Price

Details:

Product Name	Afatinib
CAS No	439081-18-2
Formula	C24H25ClFN5O3
Molecular Weight	485.93800
Synonyms	(S,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide;Tovok;BIBW2992
Exact Mass	485.16300
LogP	4.53590
Color	White powder

Afatinib is an irreversible ErbB family of blockers that suppress information transmission and block the major pathways involved in cancer cell growth and division. Because ErbB family information transduction mechanism can be triggered by multiple homodimers and heterodimers, simultaneous inhibition of multiple ErbB family members (such as EGFR, HER2, ErbB3 and ErbB4) can effectively interrupt the downstream information transduction.

    

Function

Afatinib is a drug approved for the treatment non-small cell lung carcinoma(NSCLC), developed by Boehringer Ingelheim. It acts as a angiokinase inhibitor.
Afatinib is a potent and irreversible dual inhibitor of EGFR and human epidermal growth factor receptor 2 (HER2) tyrosine kinase.White solid.

Application

 

Like lapatinib and neratinib, afatinib is a tyrosine kinase inhibitor (TKI) that also irreversibly inhibits human epidermal growth factor receptor 2 (Her2) and epidermal growth factor receptor (EGFR) kinases. Because of its additional activity against Her2, it is being investigated for breast cancer as well as other EGFR and Her2 driven cancers.

Specification

Item	Standard
Structural data confirmation	1. H-NMR: The data of structure are identical with reference standard
	2. HPLC-MS: Ensure the molecular weight of main peak and fragment peak are identical with reference standard
	3. IR:The data of IR are identical with that of reference standard
Purity(HPLC)	≥99.0%
Related impurities	Specific single impurity Meets EP/USP/BP standards
	Non-specific single impurity ≤0.10%
	Total Impurities ≤0.50%
Crystal form	Meets EP/USP/BP standards
Loss on drying	≤1.0%
Water	≤1.0%
Inorganic salt	≤0.1%
Heavy metals	≤10 ppm
Assay	99.0%~101.0%(According to EP/USP/BP standards)
Microbiological Analysis
Total plate count	≤1000cfu/g
Yeast and Moulds	≤100cfu/g
E. Coli.	Absent
Salmonella	Absent
S.aureus	Absent

 

By Express		By Air		By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods		Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed		Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

3. OEM/ODM Available.

4. Reasonable & competitive price, fast lead time.

5. Sample is available for your evaluation & Formulation development.

6. Faster delivery:Sample order in stock and 3-7 days for bulk production.

7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.

8. After-Sale Service:

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

 

 

Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount
A: Yes, for larger quantity, we always support with better price. 

Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests
Q: How to start orders or make payments
A: You can send our your Purchase order (if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.