Weight Loss Peptide Peptidomimetic Powder CAS 137525-51-0 Adipotide

Details:

What's CAS 137525-51-0 Adipotide ？

Product Name	Adipotide
Sequence	CKGGRAKDC-GG-D(KLAKLAK)2
Molecular formula	C111H204N36O28S2
Molar Mass	2555.22 g/mol
Peptide Sequence	H-Cys-Lys-Gly-Gly-Arg-Ala-Lys-Asp-Cys-Gly-Gly-Asp-(Lys-Leu-Ala-Lys-Leu-Ala-Lys)2
Appearance	white powder
Purity	>98%
Capacity	100g per month
Description	Adipotide, a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)

Adipotide is a new drug that is showing some promise in the area of obesity research. This drug was

initially created as a cancer treatment designed to starve cancer cells of a blood supply so they would

stop growing. The effects of Adipotide have shown that the drug actually starves fat cells of blood forcing

them to die and be reabsorbed into the body. Initial tests were done on rats and then moved on to

monkeys. The results from testing on rats showed a 30 percent decrease in body weight. After four weeks

of daily injections of Adipotide followed by four weeks of non-treatment, 10 obese female rhesus monkeys

lost an average of 11 percent of their body weight and 39 percent of fat deposits. Most of the loss was

experienced during the non-treatment period.

Function & Application：

Adipotide, a peptidomimetic with sequence CKGGRAKDC-GG-D(KLAKLAK)2, is an experimental proapoptotic

drug that has been shown to cause rapid weight loss in mice and rhesus monkeys. Its mechanism of action

is to target specific blood vessels supplying adipose tissue with blood, cause the vessels to shrink and

the fat cells fed by those vessels to undergo apoptosis.Adipotide is designed to bind to two receptors,

ANXA2 and prohibitin, that are specific to blood vessels supplying white adipose tissue.
 

Clinical Research studies have shown that the peptide-like compound, Adipotide, is able to kill fat cells

thereby causing a decrease in the volume and mass of the subcutaneous fat, and this in turn leads to

weight loss. Adipotide is able to kill the adipocytes (fat cells) by selectively causing programmed cell

death (apoptosis) of the blood vessels supplying the adipocytes.

Specifications	Results
Assay(HPLC)	98.0%~102.0%	99.4%
Appearance	White Lyophilized Powder	Complies
Identification	Positive Reaction	Complies
Melting point	224.0~227.0℃	224.0~226.0℃
Ash	≤0.1%	0.08%
Loss on drying	≤0.5%	0.11%
Residue on ignition	≤0.1%	0.06%
Related substance	≤1.0%	0.75%
Chloride	≤50ppm	Complies
Sulphate/Barium salt	≤60ppm	Complies
Oxalate	Pass	Complies
Fe	≤5ppm	Complies
As	≤50ppm	Complies
Heavy metals	≤1ppm	Complies

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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