Supply 99% CAS 121268-17-5 Alendronate Sodium Powder

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What's CAS 121268-17-5 Alendronate Sodium

Product:	Alendronate Sodium
Molecular formula:	C4H12NaNO7P2 • 3H2O
Molecular weight:	325.13
CAS No.:	121268-17-5
Melting Points :	245°C-257°C
Description:	White crystalline powder
Identification:	(1)physical chemistry reaction,positive reaction (2) infrared absorption atlas in accord with the reference
Acidity :	4.2 ~ 4.6

Alendronate is a bisphosphonate drug used for osteoporosis and several other bone diseases. It is marketed alone as

well as in combination with vitamin D.

Alendronate inhibits osteoclast-mediated bone-resorption. Like all bisphosphonates, it is chemically related to inorganic

pyrophosphate, the endogenous regulator of bone turnover. Whereas pyrophosphate and the first bisphosphonate,

etidronate, are capable of inhibiting both osteoclastic bone resorption as well as the mineralization of the bone newly

formed by osteoblasts, alendronate and the other potent N-containing bisphosphonates such as risedronate,ibandronate,

and zoledronate specifically inhibit bone resorption without any effect on mineralization at pharmacalogically achievable

doses. Its inhibition of bone-resorption is dose-dependent and approximately 1,000 times stronger than the equimolar

effect of etidronate. Under therapy, normal bone tissue develops, and alendronate is deposited in the bone-matrix in

pharmacologically inactive form. For optimal action, enough calcium and vitamin D are needed in the body in order to

promote normal bone development. Hypocalcemia should, therefore, be corrected before starting therapy.

   

Inspection Item		Requirements		Test Results
Appearance		White crystalline powder		Complies
Identification		A. Infrared spectrum should conform, Reaction of sodium		Complies
		B. Should conform		Complies
Chromatographic purity		Should Conform		Complies
Lose on drying		16.1% - 17.1%		16.4%
(HPLC) Individual  Known  Impurity		Individual impurity≤0.1%		Complies
		Sum of impurities≤0.5%		Complies
Heavy metals		≤ 10ppm		<10ppm
Assay( HPLC)		≥98.5%		99.5%

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

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