Supply 99% CAS 58-63-9 Inosine Powder

Details:

What's CAS 58-63-9 Inosine Powder

Product Name	Inosine
CAS NO	58-63-9
Synonyms:	Atorel;beta-D-Ribofuranoside, hypoxanthine-9;beta-Inosine;HXR;Hypoxanthine D-riboside;Hypoxanthine, 9-beta-D-ribofuranosyl-;hypoxanthined-riboside;hypoxanthinenucleoside
Molecular Formular	C10H12N4O5
Molecular Weight	268.23
Appearance	Crystalline Powder
storage	cool and dry place

Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via

a β-N9-glycosidic bond.

Inosine is commonly found in tRNAs and is essential for proper translation of the genetic code in wobble base pairs.

Knowledge of inosine metabolism has led to advances in immunotherapy in recent decades. Inosine monophosphate

is oxidised by the enzyme inosine monophosphate dehydrogenase, yielding xanthosine monophosphate, a key precursor

in purine metabolism. Mycophenolate mofetil is an anti-metabolite, anti-proliferative drug that acts as an inhibitor of

inosine monophosphate dehydrogenase. It is used in the treatment of a variety of autoimmune diseases including

granulomatosis with polyangiitis because the uptake of purine by actively dividing B cells can exceed 8 times that of

normal body cells, and, therefore, this set of white cells (which cannot operate purine salvage pathways) is selectively

targeted by the purine deficiency resulting from inherited metabolic diseases (IMD) inhibition.

Function & Application

1. Used in the treatment of leucopenia and thrombocytopenia.

2. In the treatment of acute hepatitis and chronic hepatitis and liver cirrhosis, hepatic encephalopathy.

3. Used for coronary atherosclerotic heart disease (coronary heart disease), myocardial infarction, 

rheumatic heart disease, cor pulmonale auxiliary drug use.

4. Used to prevent and mitigate the schistosomiasis prevention drugs caused by the heart and the liver toxicity.

5. Used for eye diseases (central retinal inflammation, optic atrophy) auxiliary drug use.

Items	Standards		Results
Appearance	White or off-white powder		Off-white powder
Identification	By HPLC		Complies
Melting Point	120ºC~130ºC		126ºC
Loss on Drying	≤1.00%		0.21%
Heavy Metals	≤ 10ppm		Complies
Sulfated Ash	≤ 0.10%		0.03%
Chlorine Content	17.5%~19.5%		19.3%
Arsenic Content	≤ 0.1ppm		0.09ppm
Lead VContent	≤ 3.0ppm		0.50ppm
Cadmium Content	≤ 0.1ppm		0.10ppm
Mercury Content	≤ 0.1ppm		0.10ppm
Microbiological Test	Coliforms:Negative		Negative
	Salmonella: Negative		Complies
	Total plate count: ≤1000 CFU/g		Pass
	Yeast&Mold: ≤50 CFU/g		Pass
Related Substances	Impurity A: ≤0.30%		0.18%
	Other unknown impurity: ≤0.10%		0.07%
	Total Impurities: ≤0.50%		0.42%
Assay	≥ 98.0%		99.50%
Reference Standard	USP Standard
Conclusion	The product complied to USP standard.
Storage	Preserve in tight,light-resistant containers in a cool place

 

 

 

 

 

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6. Sample is available for your evaluation & Formulation development.

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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