NSI-189 Freebase Nootropics powder CAS NO.1270138-40-3

Details:

Product name: NSI-189 Freebase

CAS: 1270138-40-3

Molecular Formula : C22H30N4O

Molecular Weight : 366.50

Appearance: Off-white powder

Structure: Our NSI-189 has a purity not less than 99%.

Solubility : Sparingly Soluble (0.070 g/L) (25 oC), Calc.*

Density : 1.134±0.06 g/cm3 (20 oC 760 Torr), Calc.*

Quality Standard: Enterprise Standard

NSI-189 is neurogenic and nootropic research agent that was developed from nicotinamide and pyrazine. Randomized controlled trials have shown that it stimulates neurogenesis or neuronal cell production in the brain. In animal studies, it has also been shown to increase the volume of hippocampus by 20% thereby reversing behavioral symptoms of depression. Such studies have shown that it may be an effective treatment for depression. It is also thought to be a promising treatment for other condition including post-traumatic stress disorder (PTSD), Alzheimer’s disease and age-related cognitive problems.

    

Benefit:

1.Nsi-189 can Enhance cognition and memory formation.

2.Nsi-189 can Anxiolytic properties.

3.Nsi-189 can Anti-depressive effect .

4.Nsi-189 can Treatment of Alzheimer's and Parkinson's disease.

5.Nsi-189 can Increase coordination.

6.Nsi-189 can Improves mood.

7.Nsi-189 can Help fight fatigue.

8.Nsi-189 can Prevent oxidation within the brain.

9.Nsi-189 can Treat alcohol related brain damage.

10.Nsi-189 can Prevent caffeine withdrawal symptoms.

 

Function & Application:

NSI-189 significantly improved behavioral responses that are associated with depression . In humans it may counter hippocampal atrophy which is seen in disorders such as MDD, reversing their symptoms. A phase 1B randomized, double-blind, placebo-controlled, multiple-dose escalation study conducted over a 28 day period showed behavioral efficacy in 24 patients who were orally administered NSI-189 . The efficacy measurements showed a clinically meaningful reduction in cognitive and depressive symptoms across all measures, and appeared to persist over time during follow up for the efficacy assessments which included the Clinical Global Impression – Improvement (CGI-I), Montgomery-Aserb Depression Rating Scale (MADRS), Cognitive and Physical Functioning Questionnaire (CPFQ, and the Symptoms of Depression Questionnaire (SDQ).

 

Specification

Item	Specifications	Results
Assay(HPLC)	98.0%~102.0%	98.9%
Appearance	Off-white crystalline powder	Complies
Identification	IR	Complies
Melting point	156.0~160.0℃	157.0~158.0℃
Loss on drying	≤0.5%	0.11%
Residue on ignition	≤0.1%	0.06%
Related substance	≤1.0%	0.75%
Heavy metals	≤10ppm	Complies

 

By Express		By Air		By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods		Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed		Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

3. OEM/ODM Available.

4. Reasonable & competitive price, fast lead time.

5. Sample is available for your evaluation & Formulation development.

6. Faster delivery:Sample order in stock and 3-7 days for bulk production.

7. We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder.

8. After-Sale Service:

1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods.

 

 

Q: What's your MOQ
A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
Q: Is there a discount
A: Yes, for larger quantity, we always support with better price. 

Q: How to confirm the Product Quality before placing orders
A: You can get free samples for some products, you only need to pay the shipping cost or arrange a courier to us and take the samples. You can send us your product specifications and requests, we will manufacture the products according to your requests
Q: How to start orders or make payments
A: You can send our your Purchase order (if your company has), or just send a simple confirmation by email or by Trade Manager, and we will send you Proforma Invoice with our bank details for your confirmation, then you can make payment accordingly.

Q: How do you treat quality complaint
First of all, our quality control will reduce the quality problem to near zero. If there is a quality problem caused by us, we will send you free goods for replacement or refund your loss.