Coluracetam Nootropics powder CAS NO.135463-81-9

Details:

Product name :Coluracetam MKC-231

CAS : 135463-81-9

Molecular Formula : C19H23N3O3

Molecular Weight : 341.40

Boiling Point:634.1°C at 760 mmHg °C

Appearance: white crystalline powder

Specification: 99% by HPLC

Coluracetam (BCI-540) is a nootropic drug of the racetam family.Coluracetam (formerly known as MKC-231) was initially developed and tested by the Mitsubishi Tanabe Pharma Corporation for Alzheimer's disease. After the drug failed to reach endpoints in its clinical trials it was in-licensed by BrainCells Inc for investigations into major depression disorder (MDD), after being awarded a "Qualifying Therapeutic Discovery Program Grant" by the state of California.Findings from its Phase 2a clinical trials have suggested that it would be an ideal medication for co-morbid MDD with generalized anxiety disorder (GAD).BrainCells Inc is currently out-licensing the drug for this purpose.It may also have potential use in prevention and treatment of ischemic retinopathy and retinal and optic nerve injury.

    

Benefit:

Coluracetam enhances high-affinity choline uptake (HACU) which is the rate-limiting step of acetylcholine (ACh) synthesis, and is the only known choline uptake enhancer to currently exist. Studies have shown Coluracetam to improve learning impairment on a single oral dose given to rats which have been exposed to cholinergic neurotoxins. Subsequent studies have shown that it may induce long-lasting procognitive effects by changing the choline transporter regulation system.

 

Function & Application:

Coluracetam is a nootropic agent of the racetam family. It may have potential use in prevention and treatment of ischemicretinopathy and retinal and optic nerve injury. Coluracetam has also been shown to reverse the loss of choline acetyltransferase production in the medial septal nucleus of rats exposed to phencyclidine (pcp), and is considered a potential therapeutic drug for schizophrenia.

The mode of action for coluracetam is still being researched, but initial studies indicate that this nootropic interacts with the process of high affinity choline uptake (HACU). This improves a neuron’s ability to create the neurotransmitter acetylcholine, which is involved with memory formation.

 

Dosage:

Due to the potency of coluracetam, the dosage is relatively low. Animal research indicates that an oral dose of 300 – 3,000 mcg/kg of bodyweight is useful, which translates to around 3.2-32.7mg overall for a human of 150 lbs. Research for human consumption is scarce, but anecdotal evidence suggests 20mg as a good starting dosage for coluracetam. Sublingual can make the impact of coluracetam far more potent.

Specification

Item	Specifications	Results
Assay(HPLC)	98.0%~102.0%	98.9%
Appearance	Off-white crystalline powder	Complies
Identification	IR	Complies
Melting point	156.0~160.0℃	157.0~158.0℃
Loss on drying	≤0.5%	0.11%
Residue on ignition	≤0.1%	0.06%
Related substance	≤1.0%	0.75%
Heavy metals	≤10ppm	Complies

 

By Express		By Air		By Sea
Suitable for under 50kg Fast: 3-7 days High cost Door to door service, easy to pick up the goods		Suitable for more than 50kg Fast: 3-7 days High cost Port to port, professional broker needed		Suitable for more than 500kg Slow: 7-45 days Low cost Port to port, professional broker needed

 

Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers, constantly strict requirements, set goals, and implement win-win development.

 

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3. OEM/ODM Available.

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5. Sample is available for your evaluation & Formulation development.

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A: For the high value product, our MOQ starts from 1g and generally starts from 10gs. For other low, price product, our MOQ starts from 100g and 1kg.
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