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Quanao supply 99% Gentamicin Powder price cas1403-66-3

Product information

         Gentamicin is one of the few thermally stable antibiotics and is therefore widely used in media configurations. China's independently developed broad-spectrum antibiotics are one of the great scientific and technological achievements since the founding of New China. Gentamicin began to be developed in 1967. Gentamicin was successfully appraised at the end of 1969. Gentamicin was named "Gentamicin,"which means celebrating the Nine Congress and celebrating the greatness of the working class. Gentamicin (gentamycin) is extracted from the fermentation broth of actinomycete monosporidium and is a basic compound. 1.Gentamicin is a commonly used aminoglycoside antibiotic. 2.Gentamicin is mainly used to treat bacterial infections,especially those caused by gram-negative bacteria. 3.Gentamicin binds to the bacterial ribosome 30s subunit and blocks bacterial protein synthesis. Gentamycin is an aminoglycoside drug.Its mechanism of action is to act on ribosomes in bacteria,inhibit bacterial protein synthesis,and destroy the integrity of bacterial cell membranes. Gentamicin can first pass through the extracellular membrane porin by passive diffusion,then enter the cell through the cell membrane via the transport system,and irreversibly binds to the isolated 30S subunit of the ribosome,resulting in destruction of the A-site, and thus:

Product Function

1.To prevent the correct localization of ammonia tRNAs in the A-position,especially to interfere with the binding of methionyl-tRNA, thereby interfering with the assembly of functional ribosomes and inhibiting the formation of the 70S initiating complex. 
2. Induced mismatch between tRNA and mRNA crypto-triad,causing the 30S subunit of the intact ribosome to misread the genetic code,causing erroneous amino acid insertion into the protein structure,resulting in abnormal,non-functional protein synthesis. 
3. Impeding the termination factor from binding to the A position, so that the synthesized peptide chain cannot be released and prevent the 70S intact ribosomes from dissociating. 
4. Blocking the depolymerization and assembly of polyribosomes,causing ribosomal depletion in bacteria. Gentamicin against Pseudomonas aeruginosa,Proteus (positive and negative),Escherichia coli, Klebsiella, Enterobacter, Serratia, Shigella, Citrobacter Neisseria, Staphylococcus aureus (excluding methicillin-resistant strains) has strong antibacterial activity. Gentamicin is not effective against streptococci (including Streptococcus pyogenes,Streptococcus pneumoniae,Streptococcus faecalis, etc.),anaerobic bacteria (Bacteroides),Mycobacterium tuberculosis,Rickettsia,viruses,and fungi.

Product Application

1.  Applicable to the treatment of sensitive bacteria caused by neonatal sepsis, sepsis. 
2. Applicable to the treatment of respiratory tract infections, peritonitis, biliary tract infections caused by sensitive bacteria. 
3. Applicable to the treatment of urogenital infections caused by susceptible strains (other than initial treatment of simple urinary tract infections).
 4. Applicable to the treatment of skin and soft tissue infections caused by susceptible bacteria,burns and other infections. 
5. Oral can be used for bowel infection or preparation before colon surgery 
6. Intramuscular injection of clindamycin or metronidazole in combination can be used to reduce the incidence of infection after colon surgery.
7. Intrathecal injection can be used as adjuvant therapy for severe central nervous system infection (acute purulent meningitis,ventriculitis)caused by Pseudomonas aeruginosa or Staphylococcus aureus. 
8. Gentamicin can also be used to treat listeriosis.
9. Gentamicin eye drops apply to coagulase-negative and positive staphylococci,Pseudomonas aeruginosa and E. coli, K. pneumoniae and other gram-negative bacilli and gonococcal conjunctivitis, keratitis,tears Bladder inflammation,blepharitis,meibomian gland inflammation,etc.

Company information

FAQ:

Q1: Can I get some samples
A: Yes, free samples(5-10g or enough to detection) are available for most of our products, you only need to pay the shipping cost.

Q2: How to confirm the quality before orders
A: Two ways, either by free samples, or send us the detailed specifications, we will arrange the production as per your 
requirement.

Q3: What's your MOQ
A: Normally 1 kg, but smaller quantity is also acceptable for some special products.
 
Q4: How about discount
A: Mainly based on quantity, also some promotional products with special discount from time to time.

Q5. What's the delivery lead time
A: 2-3 working days after payment.
 
Q6: How to make order & payment
A: Proforma invoice will be sent after your confirmation of the order, We can accept payment by T/T, ,Transfer Wise and MoneyGram.