Supply 99% CAS 130018-87-0 Levocetirizine Dihydrochloride Powder

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What's CAS 130018-87-0 Levocetirizine Dihydrochloride

Product Name:	Levocetirizine Dihydrochloride
Synonyms:	LEVOCETIRIZINE 2HCL;LEVOCETIRIZINE DIHCL;LEVOCETIRIZINE DIHYDROCHLORIDE;LEVOCETIRIZINE HCL;LEVOCETRIZINE DIHYDROCHLORIDE;[2-[4-[(r)-(4-chlorophenyl)phenylmethyl]-1-piperazinyl]ethoxy]-acetic acid dihydrochloride;[2-[4-[(R)-(4-CHLOROPHENYL)PHENYLMETHYL]-1-PIPERAZINYL]ETHOXY]-ACETIC ACID 2HCL;(R)-Cetirizine (hydrochloride)
Appearance	White Powder
CAS	130018-87-0
MF	C21H27Cl3N2O3
MW	461.81
EINECS:	641-093-3
Assay	99%
Shelf Life	24 months when properly stored
Storage	Keep in a cool, dry, dark location

Levocetirizine dihydrochloride,(R)-[2-[4-[(4-chlorophenyl) phenylmethyl]-1-piperazinyl] ethoxy] acetic acid dihydrochloride,

(Xyzal) is awhite, crystalline powder and is water soluble. This R-enantiomer is has a 30-fold higher affinity than the

S-enantiomer,and dissociates more slowly from H1-receptors.

Pharmacologically, it displays the same receptor and CNSselecitivity profile as the racemate, cetirizine,and thus the same

therapeutic advantages. Levocetirizine isindicated for the relief of symptoms associated with allergicrhinitis (seasonal and

perennial) in adults and children 6 yearsof age and older and for the treatment of the uncomplicatedskin manifestations

of chronic idiopathic urticaria in adultsand children 6 years of age and older. Its pharmacokineticsand clearance profile

are essentially the same as the racemate,cetirizine .

Application & Function

(1). Cyproheptadine is used to treat allergic reactions (specifically hay fever).[6] It is also used to treat vasomotor mucosal

edema, including vasomotor rhinitis and edema of the throat.

(2). It has shown effectiveness in the treatment of nightmares, including those related to post-traumatic stress disorder.

(3). It has been used in the management of moderate to severe cases of serotonin syndrome, a complex of symptoms

associated with the use of serotonergic drugs, such as selective serotonin reuptake inhibitors and monoamine oxidase

inhibitors), and in cases of high levels of serotonin in the blood resulting from a serotonin-producing carcinoid tumor.

(4) .It can also be used as a preventive measure against migraine in children and adolescents.

In Australia this is the only indication for which cyproheptadine is subsidised by the PBS.

(5). It can relieve SSRI-induced sexual dysfunction and drug-induced hyperhidrosis (excessive sweating).

(6). It is also used in the treatment of cyclical vomiting syndrome;

(7).Use of the drug can stimulate the appetite and may lead to weight gain, which is helpful for underweight people.

(8).According to a small study, cyproheptadine hydrochloride has been found to improve sleep, calmness, and mood

and energy levels, and to improve both negative and (sometimes even) positive psychotic symptoms in a subgroup

of chronic schizophrenics who did not respond (either completely

or sufficiently) to other therapies.

(9). Cyproheptadine may improve akathisia in patients on antipsychotic medications.

(10).In clinical trials in which cyproheptadine was used as an adjunct to antipsychotic treatment for patients with

schizophrenia, an improvement in negative symptoms was seen.

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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