Supply 99% CAS 161973-10-0 Esomeprazole Magnesium Powder

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What's CAS 161973-10-0 Esomeprazole Magnesium Powder

Product Name:	Esomeprazole magnesium
Synonyms:	Esomeprazole magnesium 5-Methoxy-2-[(S)-(4-methoxy-3,5-dimethyl-2-pyridinylmethyl)sulfinyl]-1H-benzimidazole magnesium salt;Esomeprazole Magnesium(Random Configuration);Esomeprazole magnesium;Magnesium 5-methoxy-2-[(4-methoxy-3,5-dimethylpyridin-2-yl)methylsulfinyl]benzimidazol-1-ide;Bis(5-methoxy-2-{(S)-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide) magnesium;Chebi:50309;EsoMeprazole MagnesiuM(NexiuM);EsMeprazole Magne-siuM Trihydrate
CAS:	161973-10-0
MF:	2(C17H18N3O3S)2.Mg
MW:	713.12
EINECS:	627-029-7

Esomeprazole is the latest in the class of agents called the protonpump inhibitors(PPIs). These drugs inhibit gastric

hydrochloric acid secretion by binding to hydrogen- potassium adenosinetriphosphatase (H+, K+-ATPase) in gastric

parietal cells. The PPIs' ability to provide rapid symptomatic control and their demonstrated efficacy in healing erosive

esophagitis have led them to be viewed as agents of choice for treating patients with gastric acid-related diseases,

including gastroesophageal reflux disease(GERD), gastric ulcers, and duodenal ulcers. In addition, these agents have

been shown to be effective in the treatment of Zollinger-Ellison syndrome and Barrett's esophagus. Esomeprazole is

the fourth PPI to be approved for use in the United States, following omeprazole; the other available PPIs are lansoprazole,

pantoprazole, and rabeprazole. PPIs have similar chemical structures and a shared mechanism of action. Esomeprazole,

the S-isomer of omeprazole, is the first PPI developed as a single optical isomer. Esomeprazole has an improved pharmacokinetic

profile over omeprazole (a racemic mixture of Sand Roptical isomers), resulting in more potent acid suppression.

Esomeprazole, like the other PPIs, does this by accumulating in the secretory canaliculus of the parietal cell when the cell

is secreting hydrochloric acid. After accumulating in this acidic environment, these agents are converted to a tetracyclic

sulfenamide, which binds covalently to sulfhydryl groups of H+, K+-ATPase, rendering it inactive. The enzyme's inactivation

blocks the final step of hydrochloric acid secretion into the stomach, resulting in a higher gastric pH. The covalent binding

of PPIs to H+, K+-ATPase is irreversible; restoration of gastric acid production depends on the rate of de novo proton-pump

regeneration, not how long plasma drug levels are maintained.

Application & Function 

Esomeprazole magnesium (esomeprazole magnesium), also known as omeprazole, esomeprazole he left Esso chemical name,

(S) - (-) -5- methoxy -2-{[(4- methyl two methoxy -3,5- -2- pyridyl) methyl] sulfinyl benzimidazole}-1H- magnesium salt, is a

new type of proton pump inhibitor, can the inhibition of H+/K+-ATP activity, mainly used for the treatment of gastric acid

hypersecretion induced gastric ulcer, duodenal ulcer and reflux esophagitis clinical digestive system disease.

1. For gastroesophageal reflux disease (GERD).

2.Treatment of erosive reflux esophagitis in cases.

3. long term maintenance of relapse in patients with esophagitis who have been cured.

4. Symptom control of gastroesophageal reflux disease (GERD) 

5. combined with appropriate antimicrobial therapy for the eradication of Helicobacter pylori infection related peptic ulcer healing,

and to prevent recurrence.

6. the risk of gastric ulcer is reduced in patients receiving continuous NSAID treatment.

7. for the treatment of liver and stomach of the chest and diaphragm, stomach burning pain.

8. for the treatment of stomachache Tunsuan, dysphagia, hiccup.
 

Items	Specification	Results
Appearance	White powder of crystalline powder	White crystalline powder
Specific optical rotation	+36°~+43°	+41.0°
IDENTIFICATION
HPLC	The retention time of the major peak of the sample solution corresponds to that of the system suitability solution,as obtained in the test for Enatiomeric.	Complies
UV	The UV absorption spectra of the test solution exhibit maximum absorption at 266nm,273nm and 282nm.	Complies
IR	IR spectrum of sample conforms to that of reference standard.	Complies
Reaction of chlorides	A solution of it responds to the tests for Chloride.	Complies
TESTS
Appearance of solution	Clear;not more intensely coloured than Y2 or GY2	Complies
Related substances
Impurity A	NMT 0.2%	0.01%
Impurity B	NMT 0.2%	Not found
Impurity C+D	NMT 0.8%	0.02%
Impurity F	NMT 0.2%	Not found
		0.03%(RRT:0.95)
Any other detectable impurity	NMT 0.1%	0.03%(RRT:1.2)
		0.03%(RRT:1.3)
Total impurities	NMT 1.5%	0.15%
Impurity E	NMT 0.2%	Not found
Enantiomeric	NMT 1.0%	0.02%
Residual solvents
Methanol	NMT 0.3%	Not found
Ethanol	NMT 0.5%	0.0636%
n-Butanol	NMT 0.5%	Not found
Tetrahydrofuran	NMT 0.072%	Not found
Toluene	NMT 0.089%	Not found
Ethyl acetate	NMT 0.5%	Not found
Ether	NMT 0.5%	0.0007%
Chloroben	NMT 0.036%	Not found
N-methyl formamide	NMT 0.088%	Not found
Loss on drying	NMT 0.5%	0.08%
Residue on ignition	NMT 0.1%	0.03%
Heavy metals	NMT 0.001%	Less than 0.001%
Assay(on anhydrous basis)	NLT 98.5% of C17H17Cl2N·HCl	99.6%

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

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