Octanoic acid, 6,8-...

Octanoic acid, 6,8-bis[(phenylMethyl)thio]-

Octanoic acid, 6,8-bis[(phenylMethyl)thio]-

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1 Kilogram

Negotiable

  • Min.Order :1 Kilogram
  • Purity: 99
  • Payment Terms : L/C,D/P,T/T

Keywords

alpha-lipoic acid analogue CPI-613;CPI-613 CPI-613; OCTANOIC ACID, 6,8-BIS[(PHENYLMETHYL)THIO]-;Octanoic acid, 6,8-bis[(phenylMethyl)thio]- 6,8-Bis[(phenylmethyl)thio]octanoic acid CPI-613;6,8-Bis(benzylsulfanyl)octanoic acid

Quick Details

  • Appearance:white power
  • Application:anticancer
  • PackAge:DRUMS/CARTON
  • ProductionCapacity:10|Metric Ton|Week
  • Storage:in sealed air resistant place
  • Transportation:air or sea or express delivery

Superiority:

Anqing World Chemical Co.,Ltd.Mainly responsible for the development of domestic and international business.In 2015,Haikang established the second branch,called Anqing Xuanyu Medical&Technology Co., Ltd, it is an R&D company that selects reliable technology and cooperative research partner for our corporation.
Haikang is committed to R&D,manufacture and sales of chemical raw materials API and intermediates.Meanwhile,we also provide services like product customization,process improvement,achievement transfer, etc. Through years effort,Haikang has made remarkable achievements in the R&D and production of anti-virus,antidiabetic,antineoplastic,beauty and whitening resist oxidation series API and intermediates.The main products are Ganciclovir, Sitagliptin, Vildagliptin, Silodosin and Imatinib API and Intermediates.
To deal with increasingly competition,Haikang adheres to “Customer is First,Technology is Leading,Quality is Life,Honesty for Developing”,and optimizes actively the products and better service to customers.

Details:

In vitro, CPI-613 has selective toxicity against a variety of tumor cell lines, including H460 human lung cancer cells and Saos-2 human sarcoma cells, with EC50 of 120μM and 120μM, respectively. CPI-613 interferes with the mitochondrial metabolism of H460 cancer cells, including the inhibition of PDH complex activity and cell membrane potential loss in a time- and drug dose-dependent manner. In addition, in H460 human lung cancer cells and Saos-2 human sarcoma cells, CPI-613 (240μM) can also induce apoptotic and non-apoptotic Chemicalbook cell death. In vivo study CPI-613 (25mg/kg) has effective anticancer activity in a human xenograft model of pancreatic tumor cells (BxPC-3). Similarly, CPI-613 (10mg/kg) will also have a significant tumor growth inhibitory effect in the H460 human non-small cell lung cancer mouse model. In addition, CPI-613 produces little or no side effects in many animal models within the expected therapeutic dose range, and has a maximum tolerated dose of 100 mg/kg in mice.

Devimistat (CPI-613) is a Lipoate analog that inhibits the mitochondrial enzymes pyruvate dehydrogenase (PDH) and α-ketoglutarate dehydrogenase in the NCI-H460 cell line, and interferes with the mitochondrial metabolism of tumor cells. CPI-613 can induce apoptosis of pancreatic cancer cells. Phase 2.

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