Supply CAS 15307-79-6 Diclofenac Sodium Powder

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What's CAS 15307-79-6 Diclofenac Sodium Powder

Product Name	Diclofenac Sodium
CAS No.	15307-79-6
Molecular Formula	C14H10Cl2NNaO2
Molecular Weight	318.14  g/mol
Appearance	White crystalline powder
Assay	99%

Diclofenac Sodium is the salt form of diclofenac, an active metabolite of the NSAID aceclofenac (sc-217557). Hydrolysis

of aceclofenac, an inhibitor of interleukin-1B-induced prostaglandin E2 production with no inhibitory activity against

Cox (cyclooxygenase), generates diclofenac, an inhibitor of both Cox-1 and Cox-2. Oxidation of diclofenac produces

the metabolite  4'-hydroxy diclofenac (sc-202423) which demonstrates specific inhibition of Cox-2. Inhibition of Cox

by diclofenac and 4'-hydroxy  diclofenac suppresses prostaglandin E2 synthesis, producing antiinflammatory and

analgesic effects. Diclofenac is also shown to stabilize the native tetrameric conformation of transthyretin (TTR) fibrils,

preventing the formation of insoluble amyloidogenic TTR deposits. Diclofenac Sodium is a substrate of CYP2C9.

Item	Standard	Test Result
Characteristic	Pure white crystalline powder, slightly hygroscopic	Conforms
Solubility	Sparingly soluble in water, freely soluble in	Comforms
	methanol, ethanol (96%); slightly soluble in acetone;
	practically insoluble in ether
Identify	(A) IR-Spectrum	(A)conforms
	(B) Reaction of sodium salt	(B)Positive
PH	6.5~7.5	7.13
Appearance of solution	Clear	Conforms
	Absorption of sodium salt≤0.05	0.015
Related substances	Single impurity ≤0.2%	Conforms
	Total impurity ≤0.5%
Heavy metal	≤10ppm	Conforms

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

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