Supply 99% CAS 117976-90-6 Rebeprazole Sodium Powder

Details:

What's CAS 117976-90-6 Rebeprazole Sodium Powder

Product Name:	Rebeprazole Sodium
CAS:	117976-90-6
MF:	C18H20N3NaO3S
EINECS:	211-134-6
Purity:	99%
Test Method:	HPLC
Shelf life:	2 years

Rebeprazole sodium was launched as Pariet in Japan, its first market, for the treatment of peptic ulcers including gastric

and duodenal ulcers.From 4-chloro- 2,3-dimethylpyridine N-oxide, a six step synthesis allows access to the basic skeleton

after successive condensations. Rabeprazole,a structural analog of Omeprazole, the first compound to have been marketed

in this class up to now, is reported to be a more potent inhibitor of gastric H+/K+-adenosine triphosphate (ATPase) ;

a common mechanism of action of this chemical class involves the conversion at low pH to a reactive sulphonamide

that itself binds to cysteine residues located on the enzyme. Moreover, rabeprazole showed an antibacterial activity

against Helicobacter Pylori, with a MIC90 of 1.56 μg/ml.

 

Rebeprazole sodium has a faster onset of action compared with omeprazole, but a shorter duration of action, being

extensively and rapidly metabolized in several animal species. In clinical studies in patients with gastric ulcers, 10 and

20 mg rabeprazole sodium once-daily significantly inhibited basal and stimulated acid output. Rabeprazole is awaiting

registration in the US for treatment of gastrooesophageal reflux disease (GORD) and other pathologic hypersecretory

conditions including Zollinger-Ellison syndrome.

It belongs to national second-class drug that can be used for the treatment of gastric ulcer. It can be used for the

treatment of peptic ulcer, gastroesophageal reflux disease, zollinger-ellison syndrome and other diseases.

Item	Requirements	Results
Appearance	White crystal	White crystal
Melting point	165~168	166.1~166.7
Optical rotation	-47~-50	-48.8
Organic volatile impurity	Complies	Complies
Sulphated ash	≤0.1%	0.02%
Loss on drying	≤0.5%	0.30%
Heavy metals	≤20ppm	Complies
Assay	≥98.5%	99.12%
Conclusion	Comply with the standard of the company

 

 

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

7. Faster delivery:Sample order in stock and 3-7 days for bulk production.

8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder

9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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