98% Purity Peptides Intermediate Mots-C/Mots Raw Powder CAS NO.1627580-64-6

Details:

Name:  MOTS-c
CAS No. : 1627580-64-6
Sequence:H-Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Arg-OH
Molecular formula: C101H152N28O22S2
Molecular weight :  2174.6
Purity:  95 %
Source:  synthetic
MSDS and COA: available
Appearance: White Powder
Minimum Order Quantity: 1 g
Test Method: HPLC
Storage: Lyophilized peptides although stable at room temperature for 3 months, should be stored desiccated below -18° C. Upon reconstitution of the peptide it should be stored at 4° C between 2-21 days and for future use below-18° C. 
Peptide sequence of MOTS-C:

MOTS-c was composed of Met, Arg, Trp, Gln, Glu, Met, Gly, Tyr, Ile, Phe, Tyr, Pro, Arg, Lys, Leu, and Arg residues, which were synthesized by China Peptides Co., Ltd. with over >98% purity. The peptides were dissolved in ddH2O, and aliquots were frozen at -20°C until use.
MOTS-c is a 16-amino-acid peptide encoded in the mitochondrial genome.
MOTS-c targets muscle and regulates metabolism via the folate-purine-AMPK pathway.
MOTS-c mediates mitochondrial regulation of insulin and metabolic homeostasis.
MOTS-c protects against age- and diet-dependent insulin resistance and obesity.

Benefits
Mitochondria are known to be functional organelles, but their role as a signaling unit is increasingly being appreciated. The identification of a short open reading frame (sORF) in the mitochondrial DNA (mtDNA) that encodes a signaling peptide, humanin, suggests the possible existence of additional sORFs in the mtDNA.
Here we report a sORF within the mitochondrial 12S rRNA encoding a 16-amino-acid peptide named MOTS-c (mitochondrial open reading frame of the 12S rRNA-c) that regulates insulin sensitivity and metabolic homeostasis. Its primary target organ appears to be the skeletal muscle, and its cellular actions inhibit the folate cycle and its tethered de novo purine biosynthesis, leading to AMPK activation.
MOTS-c treatment in mice prevented age-dependent and high-fat-diet-induced insulin resistance, as well as diet-induced obesity. These results suggest that mitochondria may actively regulate metabolic homeostasis at the cellular and organismal level via peptides encoded within their genome.

 

 

 

 

 

 

 

 

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Xi'an Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability of product quality from all aspects. The company has a complete sales service system, the products are exported to countries all over the world, and have won a good international reputation with excellent quality and excellent service.
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