Supply 99% CAS 877399-52-5 Crizotinib Powder

Details:

What's CAS 877399-52-5 Crizotinib Powder

Product name:	Crizotinib
CAS:	877399-52-5
MF:	C21H22Cl2FN5O
MW:	450.343
Purity:	99% min
Appearance:	White Crystalline Powder
MOQ:	10 grams
Storage:	Store in a cool, dry place
Deliver time:	About 5 days
Deliver methods:	By express (door to door)

Crizotinib (trade name Xalkori,) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1

(c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and

some other countries, and undergoing clinical trials testing its safety and efficacy inanaplastic large cell lymphoma,

neuroblastoma, and other advanced solid tumors in both adults and children.

 

Crizotinib has an aminopyridine structure, and functions as a protein kinase inhibitor by competitive binding within the

ATP-binding pocket of target kinases. About 4% of patients with non-small cell lung carcinoma have a chromosomal

rearrangement that generates a fusion genebetween EML4 ('echinoderm microtubule-associated protein-like 4') andALK

('anaplastic lymphoma kinase'), which results in constitutivekinase activity that contributes to carcinogenesis and seems

to drive the malignant phenotype.

The kinase activity of the fusion protein is inhibited by crizotinib. Patients with this gene fusion are typically younger

non-smokers who do not have mutations in either theepidermal growth factor receptor gene (EGFR) or in the K-Ras

gene.The number of new cases of ALK-fusion NSLC is about 9,000 per year in the U.S. and about 45,000 worldwide.

Application & Function 

Treating certain types of lung cancer. It may also be used for other conditions as determined by your doctor.
Crizotinib is a tyrosine kinase inhibitor. It works by preventing the growth of cancer cells.

Crizotinib inhibits the c-Met/Hepatocyte growth factor receptor (HGFR) tyrosine kinase, which is involved in the

oncogenesis of a number of other histological forms of malignant neoplasms.

Crizotinib is currently thought to exert its effects through modulation of the growth, migration, and invasion of malignant

cells.Other studies suggest that crizotinib might also act via inhibition of angiogenesis in malignant tumors.

   

Items		Standards	Results
Appearance	White or off-white solid powder		Complies
Identification	By IR		Complies
	By HPLC		Complies
Loss on Drying	≤ 0.50%		0.22%
Heavy Metals	≤ 10ppm		Complies
Residue on Ignition	≤ 0.10%		0.04%
Residual Solvents	Methylene chloride: ≤600ppm		ND
	Ethanol: ≤5000ppm		500
	Ethyl acetate: ≤5000ppm		900
	Acetonitrile: ≤410ppm		ND
Related Substances	Any single impurity: ≤0.10%		0.09%
	Total Impurities: ≤1.00%		0.48%
Purity(HPLC)	≥ 99.0%		99.52%
Assay                  (on the anhydrous basis)	98.0%~102.0%		99.68%
Reference Standard	In-house Standard
Conclusion	The product complied to In-house standard.
Storage	Preserve in tight, light-resistant containers in a cool place

 

 

 

1. All inquiries will be replied within 12 hours.

2. Dedication to quality, supply & service.

3. Strictly on selecting raw materials.

4. OEM/ODM Available.

5. Reasonable & competitive price, fast lead time.

6. Sample is available for your evaluation & Formulation development.

7. Faster delivery:Sample order in stock and 3-7 days for bulk production.

8.We have strong cooperation with DHL, TNT, UPS, FEDEX, EMS. Or you also can choose your own shipping forwarder

9. After-Sale Service:
1) International Authorized Third-Party Test For The Products You Demand.

2) 30 Days Warranty of quality of goods. 

 

Delivery & Payment Terms

Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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