Supply 99% CAS 577778-58-6 Topiroxostat Powder

Details:

What's CAS 577778-58-6 Topiroxostat Powder

Product name:	Topiroxostat
Synonyms:	FYX 051;Topiroxostat;Topiroxostat,FYX-051;5-(2-Cyano-4-pyridyl)-3-(4-pyridyl)-1,2,4-triazole;Topiroxostat 5-(2-Cyano-4-pyridyl)-3-(4-pyridyl)-1,2,4-triazole;4-[5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile;2-Pyridinecarbonitrile, 4-[5-(4-pyridinyl)-1H-1,2,4-triazol-3-yl]-;Topiroxostat impurty
CAS:	577778-58-6
MF:	C13H8N6
MW:	248.24
Boiling point:	594.7±60.0 °C

 

Topiroxostat is an orally-administered, non-purine, selective xanthine oxidase (XO) inhibitor developed for the treatment

of hyperuricemia specifically for patients with gout in Japan. The drug was discovered and developed by Fuji Yakuhin.

In contrast to conventional XO inhibitors such as febuxostat, topiroxostat interacts with key amino acid residues of the

solvent channel.


Topiroxostat, a selective xanthine oxidoreductase inhibitor, is used in Japan for the treatment of hyperuricemic patients

with or without gout. In terms of the effectiveness of topiroxostat in lowering serum urate levels, the dose-response

relationship has been evaluated; however, it remains to be verified. A randomized, multi-center, double-blinded study

of topiroxostat was performed for Japanese hyperuricemic patients with or without gout.

Items		Standards	Results
Appearance	White or off-white solid powder		Complies
Identification	By IR		Complies
	By HPLC		Complies
Loss on Drying	≤ 0.50%		0.22%
Heavy Metals	≤ 10ppm		Complies
Residue on Ignition	≤ 0.10%		0.04%
Residual Solvents	Methylene chloride: ≤600ppm		ND
	Ethanol: ≤5000ppm		500
	Ethyl acetate: ≤5000ppm		900
	Acetonitrile: ≤410ppm		ND
Related Substances	Any single impurity: ≤0.10%		0.09%
	Total Impurities: ≤1.00%		0.48%
Purity(HPLC)	≥ 99.0%		99.52%
Assay                  (on the anhydrous basis)	98.0%~102.0%		99.68%
Reference Standard	In-house Standard
Conclusion	The product complied to In-house standard.
Storage	Preserve in tight, light-resistant containers in a cool place

 

 

 

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6. Sample is available for your evaluation & Formulation development.

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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