Supply 99% CAS 34580-14-8 Ketotifen Fumarate Powder

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What's CAS 34580-14-8 Ketotifen Fumarate Powder

Name	Ketotifen fumarate
CAS No.	34580-14-8
MF:	C23H23NO5S
MW:	425.5
Purity	98%min
Certificate	ISO 9001
Appearance	White Powder

Ketotifen fumarate, also known as mepenthionone, thioperisone, sardidone, thiprone, ketotifen, is a powerful anti-allergic

drug with both tricyclic and piperidine structures. Its characteristics It has both strong histamine H1 receptor antagonism

and inhibition of the release of allergic reaction mediators. It can inhibit the release of various mediators of mast cells,

basophils and macrophages, including the release of slow-reacting substances and other active substances, has an

antagonistic effect on calcium ions, inhibits phosphorous Chemicalbook acid diesterase, and makes mast cells The

internal cAMP content increases. Inhibit the chemotaxis and inflammation of neutrophils, its effect is 10 times stronger

than chlorpheniramine, and has a long-term effect, stronger than cromolyn sodium. Ketotifen fumarate has a therapeutic

effect on type 1 and type 3 allergies. The peak blood concentration is 2 to 3 hours, the half-life is 22 hours, 60% is excreted

in urine, 40% is excreted in feces, children are excreted faster than adults, long-term treatment does not produce drug

resistance, and there is no rebound phenomenon when interrupting treatment.

Application & Function

It is widely used in a variety of IgE-mediated allergic diseases, including bronchial asthma, asthmatic bronchitis, allergic

cough, allergic rhinitis, allergic pollen, allergic conjunctivitis, acute or chronic urticaria, ectopic Dermatitis, contact

dermatitis, photosensitive dermatitis, food allergies, drug allergy, insect allergies and so on. For the immune complex

caused by vasculitis type lesions such as allergic purpura also have a certain effect.
 

Captopril is used for the treatment of various types of hypertension, especially for the treatment of intractable hypertension,

which is ineffective for other antihypertensive drugs. It can enhance the curative effect with diuretics and has a better

effect on patients with high plasma renin activity. Also used for acute and chronic congestive heart failure, better combined

with cardiotonic or diuretic.

Items	Standards
Characteristics	White to the pale yellow powder
Assay(C12H12O18P2Mg3)	≥98.5%
Loss on drying	≤20%
Heavy Metals(Pb)	≤0.001%
Arsenic	≤0.0002%
PH Value(3% aqueous solution)	7.0-8.5
Color of solution	≤70
Free ascorbic acid	≤0.5%
Free phosphoric acid	≤1%
Chloride	≤0.35%
Total aerobic count	≤1000 per gram

 

 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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