Supply Antidote Dmps Monohydrate CAS 207233-91-8

Details:

What's Antidote Dmps Monohydrate Powder

Product Name	Trazodone hydrochloride
Synonyms	TrazodonHCL;TRAZODONE HCL;TRAZODONE HYDROCHLORIDE;)-onehcl;2-(3-(4-(3-chlorophenyl)-1-piperazinyl)propyl)-s-triazolo(4,3-a)pyridin-3(2h;af1161;kb-831;molipaxin
CAS	25332-39-2
MF	C19H23Cl2N5O
MW	408.32
EINECS	246-855-5

DMPS  is a broad-spectrum antidote of heavy metals, and is also used in the therapy of hepatolenticular

degeneration, HLD (also known as Wilson's disease). DMPS effect on hydrargyrism is better than that of

dimercaptopropanol, but it has lower toxicity. DMPS is used as antidote of toxicosis from mercury, arsenic,

chromium, bismuth, copper, antimony, etc. It is also effective on hepatolenticular degeneration, HLD (Wilson's

disease) with long-term use.

DMPS is indicated for the treatment of lead poisoning in children with blood level measured above 45 µg/dL.

The use of DMPS is not approved for prophylactic/prevention of lead poisoning in anticipation of exposure

in known lead contaminated environments. Its elimination half-life is 2.5-3.5 h. DMPS can cross the blood-

brain barrier of mice, but not that of humans, limiting its use to extracting heavy metals from parts of the

body other than the central nervous system.

Another application for DMPS is for provocation of tissue heavy metals in anticipation of a urine test. This

is sometimes called a "challenge" or "provoked" heavy metals test. DMPS is used to help mobilize heavy

metals stored in body tissues (and therefore not typically present in the circulation) and increase the excretion

of heavy metals in the urine. In a study by Howard Frumkin et al., this sort of test was shown to not reliably

provide an indication of past chronic mercur exposure, something it was often used for. A 2004 study by

GP Archbold, et al. called the results of a DMPS challenge test "misleading" for the purposes of diagnosing

mercur toxicity. Moreover, DMPS share the limitation of extracellular distribution, which makes it unable to

cross the cell membrane and chelate heavy metals from intracellular sites.

The relative activities of a series of novel monoalkyl esters of 2,3-dimercapto-1-propanesulfonate Sodium

(DMPS) have been examined as agents for the mobilization of cadmium, lead and arsenic owing to the

ability of these monoesters to cross cell membranes. The monoesters were found to be more effective

than the parent compound DMPS. 

 Function & Application

DMPS is indicated for the treatment of lead poisoning in children with blood level measured above 45 µg/dL.

The use of DMPS is not approved for prophylactic/prevention of lead poisoning in anticipation of exposure in

known lead contaminated environments. Its elimination half-life is 2.5-3.5 h. DMPS can cross the blood-brain

barrier of mice, but not that of humans, limiting its use to extracting heavy metals from parts of the body other

than the central nervous system.

Another application for DMPS is for provocation of tissue heavy metals in anticipation of a urine test. This is

sometimes called a "challenge" or "provoked" heavy metals test. DMPS is used to help mobilize heavy metals

stored in body tissues (and therefore not typically present in the circulation) and increase the excretion of heavy

metals in the urine. In a study by Howard Frumkin et al., this sort of test was shown to not reliably provide an

indication of past chronic mercury exposure, something it was often used for. A 2004 study by GP Archbold,

et al. called the results of a DMPS challenge test "misleading" for the purposes of diagnosing mercury toxicity.

Moreover, DMPS share the limitation of extracellular distribution, which makes it unable to cross the cell membrane

and chelate heavy metals from intracellular sites.

The relative activities of a series of novel monoalkyl esters of 2,3-dimercapto-1-propanesulfonate Sodium

(DMPS) have been examined as agents for the mobilization of cadmium, lead and arsenic owing to the ability

of these monoesters to cross cell membranes. The monoesters were found to be more effective than the parent

compound DMPS. 

Items	Specifications	Results
Appearance	White to cream white, odorless powder	White, odorless powder
Identification (by IR)	Conforms to the GRS spectrum	+91.4°
Loss on drying	≤0.5%	0.2%
Sulphated ash	≤0.1%	0.09%
Assay(by HPLC)	97.0%~103.0%	99.7%
Related substances (by HPLC)	Any individual impurity ≤1.5% Total impurities≤ 2.0%	0.28% 0.62%
Residual solvents	Ethanol≤5000ppm Methylene chloride ≤600ppm Hexane ≤290ppm Dioxane ≤380ppm Pyridine ≤200ppm	69ppm 43ppm Undetected (LOD 3ppm) Undetected(LOD 8pppm) Undetected (LOD 4ppm)
Conclusion:   Meet the specification according to USP31.

 

 

 

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6. Sample is available for your evaluation & Formulation development.

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2) 30 Days Warranty of quality of goods. 

 

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Julong Bio-Tech Co., Ltd. is located in Xi'an City, Shaanxi Province, China. It is a biotechnology enterprise engaged

in the research, development, production and sales of animal and plant extracts, cosmetics, pharmaceutical raw materials

and intermediates. The company has complete experimental facilities. And advanced testing instruments ensure the stability

of product quality from all aspects. The company has a complete sales service system, the products are exported to countries

all over the world, and have won a good international reputation with excellent quality and excellent service.

The company has been adhering to the basic principles of "integrity, quality, service, and win-win" to serve customers,

constantly strict requirements, set goals, and implement win-win development.

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